Abnormalities in gut microbiota and serum metabolites in hemodialysis patients with mild cognitive decline: a single-cen
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ORIGINAL INVESTIGATION
Abnormalities in gut microbiota and serum metabolites in hemodialysis patients with mild cognitive decline: a single-center observational study Bin Zhu 1 & Jianqin Shen 2 & Riyue Jiang 3 & Lina Jin 2 & Gaofeng Zhan 4 & Jinfeng Liu 2 & Qi Sha 5 & Rongpeng Xu 1 & Liying Miao 6 & Chun Yang 7 Received: 14 April 2020 / Accepted: 20 May 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Rationale Although a growing body of evidence indicates that the scores of cognitive function in hemodialysis patients are significantly lower than those of healthy individuals, underlying mechanisms have not been fully elucidated. Objectives To investigate the roles of gut microbiota and serum metabolites in hemodialysis patients with mild cognitive decline (MCD). Methods A total of 30 healthy individuals and 77 hemodialysis patients were enrolled and were classified into healthy control (HC), normal cognitive function (NCF), and MCD groups by evaluation of Montreal Cognitive Assessment. Fecal samples were analyzed by 16S rRNA and serum samples were analyzed by gas chromatography-mass spectrometry from all subjects. Results The 16S rRNA study demonstrated that the gut microbiota profiles, including α- and β-diversity, and a number of 16 gut bacteria were significantly altered in the MCD group compared with those in HC or those with NCF. A metabonomics study showed that a total of 29 serum metabolites were altered in the MCD group. Receiver operating characteristic curves showed that Genus Bilophila and serum putrescine might be sensitive biomarkers to indicate MCD in patients with hemodialysis. Conclusions These findings demonstrate gut microbiota and serum metabolites were probably involved in the pathogenesis of hemodialysis-related MCD. Therapeutic strategies targeting abnormalities in gut microbiota and serum metabolites may facilitate the beneficial effects for hemodialysis patients with MCD. Keywords Hemodialysis . Mild cognitive dysfunction . Gut microbiota . Metabolites . Biomarkers
Bin Zhu, Jianqin Shen and Riyue Jiang contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00213-020-05569-x) contains supplementary material, which is available to authorized users. * Liying Miao [email protected] * Chun Yang [email protected] 1
Department of Critical Care Medicine, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China
2
The Blood Purification Center, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China
3
Department of Ultrasound Imaging, Renmin Hospital, Wuhan University, Wuhan 430060, China
4
Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
5
Department of Clinical Nutrition, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China
6
Department of Nephrology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China
7
Depar
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