ABO Blood Groups Associations with Ovarian Cancer: A Systematic Review and Meta-analysis
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REVIEW ARTICLE
ABO Blood Groups Associations with Ovarian Cancer: A Systematic Review and Meta-analysis Nazanin Razzaghi1 • Houman Seraj2 • Keyvan Heydari3,4 • Hossein Azadeh5 • Alireza Salehi4 • Morteza Behnamfar6 • Mahsa Bahadori7 • Hanie Ebrahimi8 • Mohammad Malekan4 • Negar Gholamalipour9 Received: 12 August 2020 / Revised: 21 September 2020 / Accepted: 12 October 2020 Ó Association of Gynecologic Oncologists of India 2020
Abstract Background Ovarian Cancer (OC), as the seventh most common cancer throughout the world, is one of the most lethal gynecologic malignancies in women. In addition to well-studied risk and prognostic factors of OC, such as age, obesity, stage, histology, etc., ABO blood groups associations with OC has been attracted the investigators’ focus in the recent decade. The objective of this study is to find any relationships between ABO blood groups and OC through a meta-analysis. Methods The databases of PubMed, Embase, and Web of Science were systematically searched by available MeSh terms for ‘‘Ovarian Cancer’’, and ‘‘ABO blood group’’ up to August 1, 2020. Hazard ratio (HR) or odds ratio (OR) were extracted and used from studies for outcome estimation whenever appropriate with 95% confident interval (CI). Data were analyzed using CMA v. 2.2.064. Results Fourteen papers, including 58,193 participants, entered in the systematic review. The meta-analysis indicated a substantially higher risk of developing OC in individuals with blood group A (OR 1.17, 95% CI 1.01–1.36) and AB (OR 1.27, 95% CI 1.02–1.59), but the subject was not significant in individuals with blood group B (OR 1.11, 95% CI 0.81–1.51). No associations were found between OC overall survival and blood group A (HR 1.14, 95% CI 0.79–1.64), AB (HR 1.00, 95% CI 0.69–1.45), and B (HR 0.88, 95% CI 0.58–1.33). Recurrence rates of OC for blood groups A, AB, B, and O were 30.8%, 34.3%, 33.6%, and 32.0%, respectively. Rates of mortality in different blood groups are as follows: A (31.8%), AB (31.1%), B (26.2%), and O (33.8%). Conclusion This systematic review and meta-analysis revealed a considerably increased risk of developing OC among individuals with blood group A and AB. However, no substantial impacts were found for ABO blood groups on the overall survival of the OC patients. Keywords Ovarian cancer Blood group Gynecology Mortality Survival
& Negar Gholamalipour [email protected] 1
Laboratory Sciences Research Centre, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
2
Student Research Committee, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
3
Gastrointestinal Cancer Research Center, NonCommunicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
4
Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
5
Department of Internal Medicine, Imam Khomeini Hospital, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
6
Student Research Committee, School of Medici
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