Advances and Clinical Practice in Pyrosequencing
The aim of this book is to improve pyrosequencing protocols as well as instrumentation for better clinical use by describing improvements and novel applications of pyrosequencing technology. Divided into five parts, the book’s thirty chapters explor
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Guohua Zhou · Qinxin Song Editors
Advances and Clinical Practice in Pyrosequencing
SPRINGER PROTOCOLS HANDBOOKS
For further volumes: http://www.springer.com/series/8623
Advances and Clinical Practice in Pyrosequencing Editors
Guohua Zhou Jinling Hospital, State Key Laboratory of Analytical Chemistry for Life Science, Medical School of Nanjing University, Nanjing, Jiangsu, China
Qinxin Song Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing, Jiangsu, China
Editors Guohua Zhou Jinling Hospital State Key Laboratory of Analytical Chemistry for Life Science Medical School of Nanjing University Nanjing, Jiangsu, China
Qinxin Song Key Laboratory of Drug Quality Control and Pharmacovigilance Ministry of Education China Pharmaceutical University Nanjing, Jiangsu, China
ISSN 1949-2448 ISSN 1949-2456 (electronic) Springer Protocols Handbooks ISBN 978-1-4939-3306-8 ISBN 978-1-4939-3308-2 (eBook) DOI 10.1007/978-1-4939-3308-2 Library of Congress Control Number: 2015957401 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Dedication The book is specially dedicated to Professor Hideki Kambara, an unsung hero of the human genome project.
Preface The high-throughput DNA sequencing method based on Sanger’s principle provided an efficient tool for the sequencing of the whole human genome. With the help of capillary array platform invented by Professor Kambara, the human genome project was finished two years earlier than expected. In the post-genomic era, many biomarkers related to early disease diagnosis and personalized medicine have been found by the use of next-generation DNA sequencers. Although there are several DNA sequencing tools available
