Amlodipine/atenolol overdose
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Various toxicities: case report A patient [age and sex not stated] developed aspiration pneumonia, sepsis, hypokalaemia and hypoglycaemia following overdose and poisoning with amlodipine and atenolol*. The patient presented to the emergency department at 8.30PM after consuming 30 tablets of amlodipine 5mg and atenolol 50mg along with ethanol at around at 9:30AM on 05 March 2019. Upon examination, BP was not recordable, pulse rate was 40 beats/minute, body temperature was 99°F with RR of 38 cycles/minute. The patient’s oxygen saturation was 86% and systemic examination was normal. The patient’s complete blood count revealed Hb 16.5 g/dL, platelet count 2.1 lakhs/cumm, RBC count 4.45 mill/cmm and total count of 21390 cells/cmm. Liver function tests revealed total bilirubin level of 1.73 mg/dL. The patient’s renal function tests and serum electrolytes were within normal limits. Based on the clinical presentation, a diagnosis of multiple drug poisoning leading to sepsis and aspiration pneumonia was made. The patient also had hypoglycaemia and hypokalaemia. The patient was treated with unspecified vasopressors, oxygenation and unspecified appropriate antibiotics. The patient also underwent GI decontamination with single dose of activated charcoal. Additionally, atropine, calcium salt, glucagon, crystalloid, insulin, potassium and dextrose were administered. The patient received maintenance infusions of regular insulin until hypotension [outcomes not stated]. * Country of occurrence, reporter country and primary source country not stated. Shariff MO. High-dose insulin therapy in beta-blocker and calcium channel-blocker poisoning-a rare case report. International Journal of Diabetes in Developing Countries 39 803514849 (Suppl. 1): S26 (plus poster) abstr. PP33, Nov 2019. Available from: URL: http://doi.org/10.1007/s13410-019-00782-7 [abstract]
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Reactions 14 Nov 2020 No. 1830
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