An Evaluation on the Effect of Osteoporosis on Osseointegration Around Titanium Implants in Posterior Maxilla Following
Background The surgical placement of implants into maxillary extraction sites in ovariectomized (OVX) rats could mimic implant placement in compromised bone in humans, such as is seen in osteoporosis. Purpose This study was designed to evaluate the effect
- PDF / 485,937 Bytes
- 5 Pages / 595.276 x 790.866 pts Page_size
- 109 Downloads / 191 Views
Abstract
Background The surgical placement of implants into maxillary extraction sites in ovariectomized (OVX) rats could mimic implant placement in compromised bone in humans, such as is seen in osteoporosis. Purpose This study was designed to evaluate the effects of osteoporosis on osseo-integration around titanium implants following extraction in the posterior maxilla of OVX rats. Materials and Methods Forty-four 3 month old female Sprague-Dawley rats were used in this study. The rats were randomly divided into two groups: Sham-operated group (SHAM; n = 22) and ovariectomized group (OVX; n = 22). Surface-treated screw-shaped titanium implants were immediately inserted into the mesial extraction sites of the first molar in the posterior maxilla following tooth extraction. The animals were sacrificed at either 28 or 56 days post-surgery, and undecalcified tissue sections were processed for histological analysis. Bone-to-implant contact (BIC) and bone density (BD) were evaluated. Results With a carefully planned and executed surgical implant protocol, implant placement following extraction in the posterior maxilla can produce reproducible results. The BIC and BD in the OVX group were significantly inferior to those in the SHAM group at both 28 and 56 days, which indicated that osteoporosis could reduce the amount of osseo-integration of dental implants in the posterior maxilla. Conclusion This study demonstrated that osseo-integration (BIC and BD) was inferior in implants following extraction in the posterior maxilla of OVX rats, especially in the early healing period, indicating that lower local bone quality in OVX rats can reduce early bone formation on implant surfaces. Keywords
Dental implants maxilla
Flapless surgery
N. Doan (&) Z. Du R. Crawford Q.T. Duong Y. Xiao Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia e-mail: [email protected] J. Xiao P. Reher P. Reher S. Ivanovski School of Dentistry and Oral Health, Griffith University, Gold Coast, QLD, Australia W. Xia F. Yang J. Jiang Department of Oral Implants, Affiliated Stomatological Hospital of Fujian Medical, Fuzhou, China N. Doan School of Dentistry, The University of Queensland, Brisbane, QLD, Australia
1
Osseo-integration
Post menopause
Posterior
Introduction
With the increasing utilisation of dental implant therapy, clinicians are faced with increasing challenges arising from compromised clinical scenarios encountered in those patients with medical conditions such as osteoporosis. While there is a marginally decreased osseo-integration success level, poor quality bone is not a complete contraindication for dental implant therapy [1–4]. The literature indicates incomplete and contradictory evidence regarding dental
© Springer Nature Singapore Pte Ltd. 2018 T. Vo Van et al. (eds.), 6th International Conference on the Development of Biomedical Engineering in Vietnam (BME6), IFMBE Proceedings 63, https://doi.org/10.1007/978-981-10-4361-1_103
603
604
N.
Data Loading...
