Analytical Techniques in the Pharmaceutical Sciences
The aim of this book is to present a range of analytical methods that can be used in formulation design and development and focus on how these systems can be applied to understand formulation components and the dosage form these build. To effectively desi
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Anette Müllertz Yvonne Perrie Thomas Rades Editors
Analytical Techniques in the Pharmaceutical Sciences
Advances in Delivery Science and Technology Series editor Michael J. Rathbone
More information about this series at http://www.springer.com/series/8875
Anette Müllertz • Yvonne Perrie • Thomas Rades Editors
Analytical Techniques in the Pharmaceutical Sciences
Editors Anette Müllertz Bioneer: FARMA Department of Pharmacy University of Copenhagen Copenhagen Ø, Denmark
Yvonne Perrie Strathclyde Institute of Pharmacy and Biomedical Sciences Glasgow, Scotland
Thomas Rades Department of Pharmacy University of Copenhagen Copenhagen Ø, Denmark
ISSN 2192-6204 ISSN 2192-6212 (electronic) Advances in Delivery Science and Technology ISBN 978-1-4939-4027-1 ISBN 978-1-4939-4029-5 (eBook) DOI 10.1007/978-1-4939-4029-5 Library of Congress Control Number: 2016943084 © Controlled Release Society 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC New York
Preface
Progress in all areas of the pharmaceutical sciences, from drug discovery and biopharmaceutics to drug delivery and pharmaceutical technology, has long been strongly connected to the development and application of analytical techniques. Without the development of HPLC and its application to plasma samples, there would be no plasma concentration time curves and no development of the concept of bioavailability. Without solid-state analytical techniques, like X-ray powder diffraction and thermal analysis, the importance of the solid-state form of a drug on its pharmaceutical performance could not have been studied, let alone understood, to name but two examples. This list could continue endlessly. But analytical techniques have also evolved as pharmaceutical questions have been more clearly stated. An example for this is the continuous development of dissolution testing, initially
