Animal Models in Cardiovascular Research
Animal Models in Cardiovascular Research covers both historical and recent advances in our understanding of the cardiovascular system from studies conducted in animal models. The last decade has seen an explosion in the use of very specialized congenic an
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David R. Gross
Animal Models in Cardiovascular Research Third Edition
David R. Gross Professor Emeritus University of Illinois Urbana Champaign College of Veterinary Medicine Department of Veterinary Biosciences 2001 S. Lincoln Ave. Urbana IL 61802 USA
ISBN: 978-0-387-95961-0 e-ISBN: 978-0-387-95962-7 DOI: 10.1007/978-0-387-95962-7 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2009927491 © Springer Science+Business Media, LLC 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
To Drs. Theodore S. Gross and Jeffrey M. Gross who continue the family obsession for the acquisition and dissemination of new knowledge.
Preface
This new edition of Animal Models in Cardiovascular Research describes historical and recent advances in our understanding of the cardiovascular system from studies conducted in a variety of animal models. Since the last edition, we have witnessed an explosion in the use of both congenic and transgenic animals. The use of specific knock-in and knock-out transgenic models has resulted in an avalanche of genetic, molecular, and protein-based information that, potentially, could result in an amazing new array of treatment and management options. However, the results of these studies also introduce a sometime bewildering array of redundant, overlapping, and competing molecular pathways involved in both physiological and pathological responses. This third edition is designed to provide a better basis for understanding and using animal models in the current climate of background knowledge and information. It is significantly different than the previous two editions. Chapter 1 is updated from the previous editions addressing general principles of animal selection. It also provides expanded tables of normal physiological values for easy reference. Chapter 2 covers preoperative care, preanesthesia, and chemical restraint, and includes a significantly expanded section on pain recognition and analgesia particularly in rodents. Chapter 3 provides a summary of normal cardiovascular parameters obtained from intact, awake animals. The data have been rearranged in outline rather than the previous tabular form hopefully resulting in easier reference. Chapter 4 addresses the techniques, problems, and pitfall
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