Animal Models of Acute Neurological Injuries II Injury and Mechanist
The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries.&nbs
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Animal Models of Acute Neurological Injuries II Injury and Mechanistic Assessments, Volume 1 Edited by
Jun Chen Department of Neurology and the Center for Cerebrovascular Disease Research, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Xiao-Ming Xu Departments of Anatomy & Cell Biology and Neurological Surgery, Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA
Zao C. Xu Department of Anatomy & Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA
John H. Zhang Department of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, CA, USA
Editors Jun Chen Department of Neurology and the Center for Cerebrovascular Disease Research University of Pittsburgh School of Medicine Pittsburgh, PA, USA Zao C. Xu Department of Anatomy & Cell Biology Indiana University School of Medicine Indianapolis, IN, USA
Xiao-Ming Xu Departments of Anatomy & Cell Biology and Neurological Surgery Spinal Cord and Brain Injury Research Group Stark Neurosciences Research Institute Indiana University School of Medicine Indianapolis, IN, USA John H. Zhang Department of Neurosurgery Loma Linda University School of Medicine Loma Linda, CA, USA
ISSN 1949-2448 e-ISSN 1949-2456 ISBN 978-1-61779-575-6 e-ISBN 978-1-61779-576-3 DOI 10.1007/978-1-61779-576-3 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2012933796 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Foreword The second edition of this outstanding reference book is being published in very challenging times. Ischemic and traumatic CNS injuries remain a huge public health problem throughout the world. Stroke continues to be ranked as the third leading cause of death in all developed countries and arguably the major cause of long-term disability. Within the USA alone, estimates are currently at 1.2 million stroke incidents each year, leading to over 150,000 outright deaths. The picture for traumatic brain injury (TBI) and spinal cord injury (SCI) is equally daunting and impacts the young and the very old of our population
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