Antiepileptics increase cholesterol and reduce statin efficacy
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Antiepileptics increase cholesterol and reduce statin efficacy Enzyme-inducing antiepileptic drugs (EIADs) not only inherently increase LDL and total cholesterol levels, but also induce simvastatin metabolism making it less efficacious, say researchers presenting at the 64th Annual Meeting of the American Epilepsy Society. The researchers conducted a retrospective analysis of antiepileptic drugs (both cytochrome P450-enzyme inducing and non-inducing) with and without simvastatin in 389 patients who had been taking the drugs in the 6 months prior to cholesterol level examination. Patients were recruited at an outpatient seizure clinic and the changes in total cholesterol (TC) and LDL-cholesterol levels were compared. EIADs were associated with higher levels of TC and LDL in patients who were and were not receiving statin therapy. The percentage of patients at the goal LDL level was lower in recipients of EIADs than non-EIADs (72% vs 84%), and fewer patients receiving statins and EIADs had goal LDL levels (68%), compared with those receiving non-EIADs and statins (80%). Furthermore, the dose of simvastatin in patients taking EIADs was significantly higher than for those who received nonEIADs (45.12mg vs 37.87mg). Jetter G, et al. Cross-Section Study of 389 Veterans Analyzing the Effect of AEDs on Cholesterol Levels and Simvastatin Dose Utilization in Clinical Practice. 64th Annual Meeting of the American Epilepsy Society : abstr. 2.150, 3 Dec 2010. 803049006 Available from: URL: http://www.aesnet.org
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Reactions 5 Feb 2011 No. 1337
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