Aortic and biventricular function in pediatric meningococcal septic shock survivors as assessed with MRI
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POSTER PRESENTATION
Open Access
Aortic and biventricular function in pediatric meningococcal septic shock survivors as assessed with MRI Heynric Grotenhuis1*, Hennie Knoester2, Jos J Westenberg1, Lucia JM Kroft1, Albert de Roos1 From 15th Annual SCMR Scientific Sessions Orlando, FL, USA. 2-5 February 2012 Summary Septic shock is one of the major causes of death in children and is characterized by a massive inflammatory response. To present date, no studies have been performed to assess the impact of such an ‘inflammatory hit’ on aortic wall structure and myocardial performance. This study shows that despite adequately preserved systolic biventricular function, frequently reduced aortic elasticity may indicate aortic wall pathology, being associated with biventricular hypertrophy and concomitant delayed biventricular relaxation in pediatric patients after septic shock. Background Septic shock is one of the major causes of death in children and is characterized by a massive inflammatory response. To present date, no studies have been performed to assess the impact of such an ‘inflammatory hit’ on aortic wall structure and myocardial performance. The objectives of the current study were therefore to prospectively assess aortic elasticity and biventricular systolic and diastolic function in a group of pediatric patients after meningococcal septic shock by using MRI. Methods Eighteen pediatric meningococcal septic shock survivors (8 male; mean age±standard deviation 14.5years±3.9; imaging performed 8.2years±2.4 after septic shock) treated with at least 2 inotropic and vasoconstrictive agents for 48 hours or longer and 18 for age and gender 1 Radiology, Leiden University Medical Center, Leiden, Netherlands Full list of author information is available at the end of the article
matched controls were prospectively studied. Routine MRI was used to assess aortic pulse wave velocity (PWV) and systolic and diastolic biventricular function. Independent-samples-t-test and Pearson-correlationcoefficient were used for statistical analysis.
Results Sepsis patients showed reduced aortic elasticity vs. controls (PWV in aortic arch: 4.1m/s±0.3 vs. 3.3m/s±0.5, P
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