Association of CRP levels with ARMS2 and CFH variants in age-related macular degeneration
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ORIGINAL PAPER
Association of CRP levels with ARMS2 and CFH variants in age-related macular degeneration Taiyo Shijo . Yoichi Sakurada . Yoshiko Fukuda . Seigo Yoneyama . Atsushi Sugiyama . Mio Matsubara . Wataru Kikushima . Naohiko Tanabe . Ravi Parikh . Kenji Kashiwagi
Received: 6 May 2020 / Accepted: 1 June 2020 Ó Springer Nature B.V. 2020
Abstract Purpose To investigate whether plasma high sensitivity C-reactive protein (hs-CRP) level is associated with exudative age-related macular degeneration (AMD) as well as variants of ARMS2 A69S and CFH I62V in patients with exudative AMD. Methods A case-control study was done comparing CRP among patients with exudative AMD including those with polypoidal choroidal vasculopathy, typical AMD and retinal angiomatous proliferation, and CRP were also compared between cases and controls. Plasma CRP was measured from peripheral blood
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10792-020-01460-y) contains supplementary material, which is available to authorized users. T. Shijo Y. Sakurada (&) Y. Fukuda S. Yoneyama A. Sugiyama M. Matsubara W. Kikushima N. Tanabe K. Kashiwagi Department of Ophthalmology, University of Yamanashi, Shimokato 1110, Chuo, Yamanashi 409-3898, Japan e-mail: [email protected] R. Parikh School of Medicine, New York University, New York, NY, US R. Parikh Manhattan Retina and Eye Consultants, New York, NY, US
using latex nepherometry for all participants. Genotyping of ARMS2 A69S and CFH I62V was performed for all patients with exudative AMD using TaqMan technology. Results Among 125 patients with exudative AMD, including 31 with typical neovascular AMD, 73 with PCV and 21 with RAP lesions and 150 controls, CRP levels were higher in exudative AMD than in controls. (P = 2.7 9 10–5) There was not a significant difference in hs-CRP levels among AMD subtypes. Neither variants of ARMS2 nor CFH was associated with hsCRP level in patients with exudative AMD. A multiple regression analysis revealed that gender male, presence of exudative AMD and presence of cardiovascular diseases were associated with increased plasma hsCRP. Conclusions Plasma hs-CRP was elevated independent of variants of ARMS2 A69S and CFH I62V in patients with exudative AMD. Keywords C-reactive protein Exudative agerelated macular degeneration ARMS2 A69S CFH I62V
Introduction Age-related macular degeneration (AMD), a major cause of irreversible vision loss among the elderly older than 55 years in the developed countries, has
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been thought to be a chronic inflammatory disease [1]. Advanced AMD is subdivided into exudative AMD or geographic atrophy; in Japan, exudative AMD accounts for about 95% of advanced AMD [2]. C-reactive protein (CRP) is an acute-phase reactant that is mainly synthesized in the liver and adipocyte and is a multifunctional, non-specific marker for systemic inflammation [3]. It has been reported that that elevated plasma CRP
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