Association of FKBP5 genotype with depressive symptoms in patients with coronary heart disease: a prospective study
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PSYCHIATRY AND PRECLINICAL PSYCHIATRIC STUDIES - ORIGINAL ARTICLE
Association of FKBP5 genotype with depressive symptoms in patients with coronary heart disease: a prospective study Julia Brandt1 · Katharina Warnke1 · Silke Jörgens1 · Volker Arolt1 · Katja Beer2 · Katharina Domschke3 · Wilhelm Haverkamp4 · Stella L. Kuhlmann5,6 · Jacqueline Müller‑Nordhorn6,7 · Nina Rieckmann6 · Kathrin Schwarte1 · Andreas Ströhle2 · Mira Tschorn2,8 · Johannes Waltenberger9 · Laura Grosse1,10 Received: 18 March 2020 / Accepted: 10 August 2020 © The Author(s) 2020
Abstract Depression and coronary heart disease (CHD) are prevalent and often co-occurring disorders. Both have been associated with a dysregulated stress system. As a central element of the stress system, the FKBP5 gene has been shown to be associated with depression. In a prospective design, this study aims to investigate the association of FKBP5 with depressive symptoms in CHD patients. N = 268 hospitalized CHD patients were included. Depressive symptoms were measured using the Hospital Anxiety and Depression Scale (HADS-D) at four time points (baseline, and after 1 month, 6 months, and 12 months). The functional FKBP5 single-nucleotide polymorphism (SNP) rs1360780 was selected for genotyping. Linear regression models showed that a higher number of FKBP5 C alleles was associated with more depressive symptoms in CHD patients both at baseline (p = 0.015) and at 12-months follow-up (p = 0.025) after adjustment for confounders. Further analyses revealed that this effect was driven by an interaction of FKBP5 genotype with patients’ prior CHD course. Specifically, only in patients with a prior myocardial infarction or coronary revascularization, more depressive symptoms were associated with a higher number of C alleles (baseline: p = 0.046; 1-month: p = 0.026; 6-months: p = 0.028). Moreover, a higher number of C alleles was significantly related to a greater risk for dyslipidemia (p = .016). Our results point to a relevance of FKBP5 in the association of the two stress-related diseases depression and CHD. Keywords Depressive symptoms · FKBP5 · HPA axis · CHD · Gene environment interaction · Stress-related disease
* Julia Brandt [email protected] 1
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, Charité-Universitätsmedizin Berlin, Corporate member of the Freie Universität Berlin, Humboldt-Universität zu Berlin, and the Berlin Institute of Health, Division of Emergency and Acute Medicine (CVK, CCM), Berlin, Germany
Department of Psychiatry and Psychotherapy, University Hospital Münster, Albert‑Schweitzer‑Campus 1, Geb. A9, 48149 Münster, Germany
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Charité-Universitätsmedizin Berlin, Corporate member of the Freie Universität Berlin, Humboldt-Universität zu Berlin, and the Berlin Institute of Health, Department of Psychiatry and Psychotherapy, Berlin, Germany
, Charité-Universitätsmedizin Berlin, Corporate member of the Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Institute of Public Health, Berlin, Germany
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Department of Psychiatry and Psychoth
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