Association of microRNA-224-3p and microRNA-155-5p expressions with plasma long pentraxin 3 concentration and coronary m
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BMC Research Notes Open Access
RESEARCH NOTE
Association of microRNA‑224‑3p and microRNA‑155‑5p expressions with plasma long pentraxin 3 concentration and coronary microvascular obstruction following primary angioplasty for acute ST‑segment elevation myocardial infarction Surya Dharma1* , Iwan Dakota2, Shoma Wijaya3, Elok Ekawati3, Renan Sukmawan2 and Bambang Budi Siswanto2
Abstract Objective: Pro-inflammatory stimuli induce a variety set of microRNAs (miRs) expression that regulate long pentraxin-3 (PTX3) protein, which associates with a procoagulant state in the endothelial cells. We evaluated, for the first time in human, the association of miR-224-3p and miR-155-5p expressions with plasma PTX3 concentration and coronary microvascular obstruction (MVO) in patients with acute ST-segment elevation myocardial infarction (STEMI) with symptom onset ≤ 12 h and treated by primary angioplasty. Blood samples for miRs and PTX3 measurement were drawn at emergency department presentation, and were measured by TaqMan real-time PCR and human ELISA kit, respectively. Results: Of the 217 patients (median age: 54 years, male: 88%), 130 (60%) had angiographic MVO. Spearman analysis showed no correlation between miR-224-3p and miR-155-5p expressions with plasma PTX3 concentration. After adjustment with sex, age, diabetes mellitus, and plasma PTX3 concentration, miR-224-3p ≥ median group was associated with angiographic MVO (odds ratio, 2.60; 95% confidence interval, 1.24 to 5.44, p = 0.01). This study suggests that miR-224-3p and miR-155-5p expressions did not correlate with plasma PTX3 concentration. However, miR-224-3p expression associates with angiographic MVO following primary angioplasty for STEMI. Future studies are needed to identify the specific gene/protein related with miR-224-3p expression in MVO. Keywords: Inflammation, microRNA, MVO, STEMI
*Correspondence: [email protected] 1 Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia Full list of author information is available at the end of the article
Introduction Coronary microvascular obstruction (MVO) during primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) associates with a worse clinical outcome [1]. Interestingly, the genetic profile and PTX3 concentration have been known to be associated with coronary MVO [2, 3]. Understanding the basic molecular mechanism of MVO
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