Basic: B io-Inspired A ssembly of S emiconductor I ntegrated C ircuitsod]20110317
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BASIC: Bio-Inspired Assembly of Semiconductor Integrated Circuits• R. Bashir1,2,♣, S. Lee1, D. Guo1, M. Pingle3, D. Bergstrom3, H. A. Mcnally1, D. Janes1 1 School of Electrical and Computer Engineering, 2Department of Biomedical Engineering, 3 Dept. of Medicinal Chemistry, Purdue University, W. Lafayette, IN. 47906 ABSTRACT In the recent years, biologically-inspired self-assembly of artificial structures, some with useful optical properties, has been demonstrated. However, to date there has been no demonstration of self-assembly of useful electronic devices for the construction of complex systems. In this paper, a new process called BASIC (Bio-Inspired Assembly of Semiconductor Integrated Circuits) is proposed. The main theme is to use the mutual binding (hybridization) and specificity of DNA strands (oligonucleotides) for the assembly of useful silicon devices on silicon or other substrate. These devices need to be ‘released’ from their host substrate into a liquid medium where they can be functionalized with single stranded DNA. Silicon-on-insulator (SOI) substrates, which naturally lend themselves for such application, due to the presence of an oxide layer underlying the silicon layer, are used. These devices can vary in size and have a thin gold layer on one surface. This approach can be used to assemble micro and nano-scale devices and circuits and can also be a powerful technique for heterogeneous integration of materials (e.g. Si on Glass or polymer). The general idea of the BASIC process can also be extended to be used with any antibody/antigen complex. Preliminary results regarding the fabrication and release of the device islands will be presented. In addition, surface AFM characterization of the gold surfaces, prior to attachment of bio-molecules, is also presented. INTRODUCTION There has been a tremendous interest in the recent years to develop concepts and approaches for self-assembled systems for electronic and optical applications [1,2]. Material selfassembly has been demonstrated in a variety of semiconductor materials (GaAs, InSb, SiGe, etc) using Stranksi-Krastanov strain-dependent growth of lattice mismatch epitaxial films [3-5]. While significant work continues along that direction, it has also been recognized by engineers, chemists, and life scientists that the exquisite molecular recognition of various natural biological materials can also be used for a variety of optical, electronic, and sensing applications. This approach can be considered a ‘bottom-up’ approach rather than the ‘top-down’ approach of conventional scaling and much work has been reported towards this front [6]. Pioneering research extending over a period of more than 15 years by N. C. Seeman has laid a foundation for the construction of structures using DNA as scaffolds, which may ultimately serve as frameworks for the construction of nanoelectronic devices [7,8]. Among roles envisioned for nucleic acids in nanoelectronic devices, the self-assembly of DNA conjugated nano-particles have received the most attention in recent lite
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