Biobetters Protein Engineering to Approach the Curative

Over the last few decades, biopharmaceuticals have transformed many areas of healthcare and have given hope and extended the lives of many patients. Curative treatments, however, remain elusive in most cases. This book describes strategies to develop impr

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Amy Rosenberg Barthélemy Demeule Editors

Biobetters Protein Engineering to Approach the Curative

AAPS Advances in the Pharmaceutical Sciences Series The AAPS Advances in the Pharmaceutical Sciences Series, published in partnership with the American Association of Pharmaceutical Scientists, is designed to deliver well written volumes authored by opinion leaders and authorities from around the globe, addressing innovations in drug research and development, and best practice for scientists and industry professionals in the pharma and biotech industries. For more details and to see a list of titles in the Series please visit http://www.springer. com/series/8825 Series Editors Daan J.A. Crommelin Robert A. Lipper

More information about this series at http://www.springer.com/series/8825

Amy Rosenberg • Barthélemy Demeule Editors

Biobetters Protein Engineering to Approach the Curative

Editors Amy Rosenberg Division of Biotechnology Review and Research III Office of Biotechnology Products Center for Drug Evaluation and Research Food and Drug Administration Silver Spring, MD, USA

Barthélemy Demeule Genentech, Inc. South San Francisco, CA, USA

ISSN 2210-7371 ISSN 2210-738X (electronic) AAPS Advances in the Pharmaceutical Sciences Series ISBN 978-1-4939-2542-1 ISBN 978-1-4939-2543-8 (eBook) DOI 10.1007/978-1-4939-2543-8 Library of Congress Control Number: 2015939911 Springer New York Heidelberg Dordrecht London © American Association of Pharmaceutical Scientists 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)

Preface

…and what never frees us from the cost of knowledge, which is to act on what we know again and again Marge Piercy, American poet

Curative or preventive therapies for human and animal diseases would provide optimal benefit, not only to individual patients in terms of quality and quantity of life but as well to the healthcare sy