Biomarkers in Neoplastic Neuropathology
This book is a rich source of information on biomarkers applicable to the pathology of neoplastic disorders of the brain. Thorough descriptions are provided of the techniques currently available for clinical and experimental evaluation of biomarkers in br
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Biomarkers in Neoplastic Neuropathology
Fausto Rodriguez • Cheng-Ying Ho
Biomarkers in Neoplastic Neuropathology
Fausto Rodriguez Pathology Johns Hopkins University Baltimore, Maryland USA
Cheng-Ying Ho Pathology Children’s National Medical Center Washington, D.C., District of Columbia USA
ISBN 978-3-319-20930-2 ISBN 978-3-319-20931-9 DOI 10.1007/978-3-319-20931-9
(eBook)
Library of Congress Control Number: 2016933123 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
To Olivia, a little sunshine that brightens my everyday (FR) To my husband Chris, for years of love and support (CH)
Contents
1
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Current Biomarkers in Neoplastic Neuropathology . . . . . . . . . . . . . . . . . Biomarker Types . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Diagnostic Biomarkers. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Prognostic Biomarkers. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Predictive Biomarkers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Monitoring Biomarkers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . What Makes for Good Biomarkers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Biosources for Biomarker Discovery and Testing . . . . . . . . . . . . . . . . . . . Tumor Tissues . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Body Fluids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Imaging Technology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ca
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