Cardiovascular Pharmacogenetics
The Human Genome Project was sold to the general public largely on the basis that a complete picture of the structure of human DNA would lead to new and better medicines. These medicines would be better because they would be tailored to individual patient
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Volume 160 Editor-in-Chief K. Starke, Freiburg i. Br. Editorial Board G.V.R. Born, London M. Eichelbaum, Stuttgart D. Ganten, Berlin H. Herken t, Berlin F. Hofmann, Miinchen L. Limbird, Nashville, TN W. Rosenthal, Berlin G. Rubanyi, Richmond, CA
Springer-Verlag Berlin Heidelberg GmbH
Cardiovascular Pharmacogenetics Contributors E.D. Abel, A.R. Boobis, J.M.e. Connell, V.J. Dzau, R.J. Edwards, D.B. Goldstein, D.O. Haskard, A.M. Henney, M.M. Hoffmann, P.L. Huang, J. W. Knowles, D. Kong, K. Lindpaintner, W. Marz, A.J. Marian, J.J.V. McMurray, L.G. Melo, K.M. O'Shaughnessy, A.S. Pachori, R.M. Rao, D. M. Roden, A.1. Russell, T. Shiga, T. Stanton, S. K. Tate, E.G.D. Tuddenham, A. Vidal-Puig, T. Vyse, M.R. Wilkins, B. R. Winkelmann Editor
Martin R. Wilkins
Springer
Professor Martin R. Wilkins Experimental Medicine & Toxicology Imperial College London Hammersmith Campus Du Cane Road London W12 ONN United Kingdom e-mail: [email protected]
With 34 Figures and 28 Tables ISSN 0171-2004 ISBN 978-3-642-07291-8 Library of Congress Cataloging-in-Publication Data Cardiovascular pharmacogenetics 1 contributors, E. D. Abel ... let a1.]. ; editor, Martin R. Wilkins. p. ; cm. - (Handbook of experimental pharmacology; v. 160) Includes bibliographical references and index. ISBN 978-3-642-07291-8 ISBN 978-3-662-06214-2 (eBook) DOI 10.1007/978-3-662-06214-2 1. Heart-Diseases-Genetic aspects. 2. Heart-Diseases-Genetic aspects. 3. Heart-Effect of drugs on-Genetic aspects. 4. Pharmacogenetics. I. Abel, E. D. (E. Dale) II: Wilkins, Martin R., 1956- III. Series. [DNLM: l. Cardiovascular Agents-therapeutic use. 2. Pharmacogenetics-methods. 3. Cardiovascular Diseases-drug therapy. 4. Cardiovascular Diseases-genetics. QV 150 C2745 20041 QP905.H3 vol. 160 IRC682] 615'. s-dc2l [615'.71] 2003054275 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag Berlin Heidelberg GmbH. Violations are liable for Prosecution under the German Copyright Law. springeronline.com © Springer-Verlag Berlin Heidelberg 2004
Originally published by Springer-Verlag Berlin Heidelberg New York in 2004 Softcover reprint of the hardcover 1St edition 2004 The use of general descriptive names, registered names, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the r
