Catheter sensor system for in-situ breathing and optical imaging measurements at airway in inside of lung
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TECHNICAL PAPER
Catheter sensor system for in-situ breathing and optical imaging measurements at airway in inside of lung Y. Maeda1 • C. Okihara1 • Y. Hasegawa1 T. Kawabe2 • M. Shikida1
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K. Taniguchi1 • M. Matsushima2 • T. Sugiyama3
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Received: 1 April 2020 / Accepted: 6 April 2020 Ó Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract A catheter sensor system composed of a tube flow sensor with a medical basket forceps and an optical fiberscope was systemized for in-situ measurements in the airway in the lung system. The tube flow sensor was produced by assembling the sensor film containing two heaters onto the tube surface, and the basket forceps was installed into the inside space of the tube sensor. The assembled tube flow sensor with the basket forceps was inserted into the tube and was fixed at the center of the tube by expanding the basket. The flow detection characteristics of the tube flow sensor were experimentally evaluated. A calibration equation based on King’s law was derived from the sensor output vs. flow velocity curve, and a sufficiently short response time of 60 ms was obtained for the breathing measurements in a rabbit and a person. Finally, the tube flow sensor with the basket forceps and the optical fiberscope was systemized into a single tube with the diameter of 5.0 mm for in-situ measurements in the airway. The developed system successfully detected both a breathing airflow waveform and an optical image inside the airway in the rabbit.
1 Introduction Micro electro mechanical systems (MEMSs) have been developed on the basis of semiconductor technologies and have miniaturized mechanical components that have multiple electrical circuits on the same Si substrate (Muller et al. 1991; Ristic 1994; Senturia 2001; Gianchandani et al. 2008). Various types of miniaturized sensors have been produced by MEMS (e.g., pressure, acceleration, gyro, and flow-sensors) and are now widely used for detecting physical values related to people’s daily activities. On the medical front, because minimally invasive treatment and in-situ measurements within limited space inside the body are often required, the miniaturization of the medical device systems has been thought to be a promising
& Y. Hasegawa [email protected] 1
Department Biomedical Information Sciences, Hiroshima City University, Hiroshima, Japan
2
Department of Medical Technology, Nagoya University, Nagoya, Japan
3
Department of Thoracic Surgery, Nagoya University, Nagoya, Japan
application of MEMS technologies ever since the early stage of their development in the late 19800 s. As the example of minimally invasive treatment, a miniaturized manipulator driven by fluid force was developed and used for applying tissue onto eye balls (Kusuda et al. 2007; Watanabe et al. 2007). This technology was also used to remove a button battery ingested into the esophagus accidentally (Choi et al. 2011). In the case of insitu measurements inside the body, a micro-machined pressure sen
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