Cell Aging: Molecular Mechanisms and Implications for Disease
Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a vari
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Christian Behl · Christine Ziegler
Cell Aging: Molecular Mechanisms and Implications for Disease
SpringerBriefs in Molecular Medicine
For further volumes: http://www.springer.com/series/13102
Christian Behl Christine Ziegler •
Cell Aging: Molecular Mechanisms and Implications for Disease
123
Christian Behl Christine Ziegler Institute for Pathobiochemistry University Medical Center of the Johannes Gutenberg University Mainz Mainz Germany
ISSN 2197-7925 ISBN 978-3-642-45178-2 DOI 10.1007/978-3-642-45179-9
ISSN 2197-7933 (electronic) ISBN 978-3-642-45179-9 (eBook)
Springer Heidelberg New York Dordrecht London Library of Congress Control Number: 2013955258 The Author(s) 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Aging is Unquestioningly Complex
(Thomas B. L. Kirkwood1)
1
Kirkwood TB (2011) Systems biology of ageing and longevity. Philos Trans R Soc Lond B Biol Sci 366(1561):64–70
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Acknowledgments
First of all, the authors wish to think Michael Plenikowski for his excellent artwork. Furthermore, gratitude is given to Christof Hiebel, Andreas Kern, and Bernd Moosmann for supplying data from their own work that are included and for many stimulating discussions on the topic. The scientific work of the authors on aging which is cited and in
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