Classification of malignant lymphoma subtypes in Korean patients: a report of the 4th nationwide study
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ORIGINAL ARTICLE
Classification of malignant lymphoma subtypes in Korean patients: a report of the 4th nationwide study Hye-Ra Jung 1 & Jooryung Huh 2 & Young-Hyeh Ko 3 & Yoon Kyung Jeon 4 & Sun Och Yoon 5 & Se Hoon Kim 5 & Woo Ick Yang 5 & Geongsin Park 6 & Jo Heon Kim 7 & Jin Ho Paik 8 & Jae Ho Han 9 & Hee Jung Cha 10 & Kyu Yun Jang 11 & Bong-Kyung Shin 12 & Young-A Kim 13 & Ji Eun Kim 13 & Yoo Duk Choi 14 & Min Gyoung Park 15 & Hee Kyung Kim 16 & Suk Jin Choi 17 & Bo Mi Kim 18 & Jong Sil Lee 19 & Hee-Kyung Chang 20 & Ji-Young Choe 21 & Soo Kee Min 21 & Dae Woon Eom 22 & Min-Sun Cho 23 & Seol Bong Yoo 24 & Wook Youn Kim 25 & Hyekyung Lee 26 & In Ho Choi 27 & Yo Sep Chong 28 & Hyang Im Lee 29 & Ho Jung Lee 30 & Seung-Sook Lee 31 & Hyun-Jung Kim 32 Received: 2 May 2019 / Accepted: 20 August 2019 # Springer-Verlag GmbH Germany, part of Springer Nature 2019
Abstract To determine the relative frequency and change of malignant lymphoma in Korea according to the 4th World Health Organization (WHO) classification and compare with previous reports. Between 2015 and 2016, 7737 new patients with malignant lymphoma were enrolled from 31 institutes, with their clinicopathologic information obtained, and evaluated for the relative frequency of lymphoma subtypes. The relative frequency of non-Hodgkin lymphoma (NHL) was 94.8%, and that of Hodgkin lymphoma (HL) was 5.2%. B cell lymphomas accounted for 83.1% of all NHLs; T/natural killer (NK) cell lymphomas, 16.4%; and immunodeficiency-associated lymphoproliferative disorders, 0.5%. The most common NHL subtypes were diffuse large B cell (41.5%), extranodal marginal zone (MALT, 19.8%), follicular (7.5%), NK/ T cell (4.2%), and peripheral T cell lymphomas, not otherwise specific (PTCL, NOS, 3.4%). Nodular sclerosis was the predominant HL subtype (48.5%), followed by mixed cellularity (28.7%), lymphocyte-rich (6.8%), lymphocyte-depleted (1.5%), lymphocyte-predominant (2.8%), and unclassified HL (11.8%). Compared with a previous report, increased B cell lymphomas (77.6–83.1%) and slightly decreased NK/T cell lymphomas and PTCL were observed. The incidence of follicular lymphoma increased by more than 2.5-fold (2.9–7.5%). Incidence rates of newly diagnosed lymphomas were lower for HL and higher for extranodal NHL, MALT, and nasal type NK/T cell lymphomas in Korea than those in Western countries. A slight increase in the relative frequency of B cell lymphoma and a prominent increase in follicular lymphoma may be attributed to refined diagnostic criteria and Westernized disease patterns. Keywords Incidence . Malignant lymphoma . WHO classification . Korea
Background and aim Malignant lymphoma represents a diverse group of malignant lymphoid neoplasms comprising B, T, and natural killer (NK) This work was supported by 2017’ Study group Supporting Program of Korean Society of Pathologists. The above co-authors are members of Korean Society of Hematopathology. This result was presented at the 14th Japanese-Korean Lymphoreticular Workshop 2018 (January 26–27, 2018, Hakone, Japan) and the
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