Clear cell tumor of the lung: a case report and literature review
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WORLD JOURNAL OF SURGICAL ONCOLOGY
CASE REPORT
Open Access
Clear cell tumor of the lung: a case report and literature review Guang-xian Wang1, Dong Zhang1, Xin-wei Diao2 and Li Wen1*
Abstract Clear cell tumor of the lung is a rare and benign pulmonary tumor; only sporadic cases have been reported. Here, we report the case of a 38-year-old man with recurrent cough, blood-streaked sputum and left chest pain. A chest computed tomography scan showed a round, homogeneous pulmonary mass in the left lower lobe, which exhibited intense heterogeneous enhancement in the arterial phase and homogeneous in the delay phase after injecting a contrast agent. The patient underwent a fine-needle aspiration biopsy and was diagnosed as having a benign clear cell tumor of the lung. The clinical presentation and radiographic investigation of this tumor are summarized in this paper to recognize this rare disease. Interestingly, we found some differences with previously reported cases. Keywords: Clear cell tumor, Sugar tumor, Lung
Background Clear cell tumor of the lung (CCTL) is a rare and benign pulmonary neoplasm, which was originally described by Liebow and Castleman in 1963 [1]. CCTL most likely arises from perivascular epithelioid cells (PECs) [2-4]. As it contains abundant cytoplasmic periodic acid-Schiff (PAS)-positive glycogen, CCTL has been termed “sugar tumor” [5]. The tumor cells show immunoreactivity for the S-100 protein and HMB-45 and no cytokeratin reactivity, which establish a definitive diagnosis [6]. Although the tumor has been well defined, only sporadic cases have been reported in the literature. Here, we report on a CCTL case and summarize a literature review of 55 CCTL cases. Our aims were to identify the clinical and radiological features of CCTL and determine the effect of CCTL tumor size. Case presentation A 38-year-old man was admitted to our hospital because of recurrent cough, blood-streaked sputum for 2 months, left chest pain for 10 days, and worsening health for 3 days. The patient, who had no known family history of cancer, was an 18 pack/year smoker. He did not * Correspondence: [email protected] 1 Department of Radiology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China Full list of author information is available at the end of the article
report any fever, night sweating, chest tightness, weight loss, or wheezing. A physical examination did not show any abnormalities, and the results of laboratory studies were unremarkable. Chest non-enhanced computed tomography (CT) scans showed a demarcated, round, homogeneous lesion of approximately 3.4 cm in diameter without evidence of calcification, necrosis, cavitation, or satellite lesions in the left lower lobe (Figure 1A), with a CT value of 46.6 Hounsfield units. A contrast-enhanced CT scan of the solitary pulmonary mass showed intense heterogeneous enhancement in the arterial phase (Figure 1B) and a homogeneous nature in the delay phase (delay 150 seconds) (Figure 1C). Abdominal CT scans showed no evidence of renal disease. Us
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