Clinical and survival analysis of 36 cases of primary fallopian tube carcinoma
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WORLD JOURNAL OF SURGICAL ONCOLOGY
RESEARCH
Open Access
Clinical and survival analysis of 36 cases of primary fallopian tube carcinoma Ying Ma1 and Wei Duan2*
Abstract Background: Primary fallopian tube carcinoma (PFTC) is rarely seen clinically. Herein, we investigate the clinical and pathological characteristics and appropriate therapies for PFTC. Methods: A total of 36 patients for whom PFTC was pathologically confirmed from January 2001 to July 2011 in Beijing Hospital of Gynecology and Obstetrics, an affiliate of Capital Medical University, were retrospectively analyzed. Results: A total of 36 cases underwent surgical staging in our hospital: 47.2% were early stage cases , and 52.8% were advanced stage cases. Of the 36 cases, 24 cases were pure adenocarcinoma, 10 cases were mixed, and there was 1 case of undifferentiated carcinoma, 1 case of undifferentiated carcinoma combined with transitional cell carcinoma, 5 cases of moderately differentiated carcinoma, and 29 cases of moderately to poorly differentiated carcinoma. There were no cases of highly differentiated carcinoma. Among the cases examined, 38.9% (14/36) had omentum metastasis, and 19 cases had an elevated CA125 during a preoperative biochemical laboratory test. Approximately 35 cases received postoperative adjuvant chemotherapy. The 3-year and 5-year overall survival rates for the 36 cases were 80.7% and 65.4%, respectively. Single-factor analysis showed that the pathological conditions of residual tumor diameter >1 cm (P 1 cm (P = 0.019) and omentum metastasis (P = 0.015) were associated with prognosis, and were, therefore, the independent risk factors of prognosis. Conclusions: PFTC is a rare female genital tract malignancy. Most patients are in an advanced stage at diagnosis, which results in a poor prognosis. Complete surgical staging and maximal resection should be recommended. Keywords: Primary fallopian tube carcinoma, CA125, Risk factors
Background Fallopian tube cancer is a rare malignancy, accounting for 0.5% of female genital cancer. It is divided into primary and secondary carcinoma, of which secondary malignancies are more often the results of metastasis of tubal ovarian cancer or endometrial stumbled cancer [1]. Primary fallopian tube carcinoma (PFTC) is rarely seen clinically due to hidden lesions, an absence of recommended screening methods, and relatively limited clinical experience, to * Correspondence: [email protected] 2 Oncology Department, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, 251, Yaojiayuan Street, Chaoyang District, Beijing 100026, China Full list of author information is available at the end of the article
the extent that a number of cases have been accidentally detected during other gynecological surgeries [2]. Because the tubal wall has considerable flexibility, even if the tube is filled with fluid or tumor, the tubal wall can still remain quite complete. Intraluminal tubal fluid can be discharged through the uterus-vagina route when fimbria atresia occurs, and this is usually fou
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