Clinical characteristics as predictors of malignancy in patients with indeterminate thyroid cytology: a meta-analysis
- PDF / 648,783 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 18 Downloads / 223 Views
META-ANALYSIS
Clinical characteristics as predictors of malignancy in patients with indeterminate thyroid cytology: a meta-analysis Pierpaolo Trimboli • Giorgio Treglia • Leo Guidobaldi • Enrico Saggiorato Giuseppe Nigri • Anna Crescenzi • Francesco Romanelli • Fabio Orlandi • Stefano Valabrega • Ramin Sadeghi • Luca Giovanella
•
Received: 25 July 2013 / Accepted: 5 September 2013 / Published online: 3 October 2013 Ó Springer Science+Business Media New York 2013
Abstract Indeterminate thyroid nodules (ITN) constitute the gray zone of thyroid fine-needle aspiration cytology (FNAC). About 70–80 % of ITN are later diagnosed as benign; therefore, it is very important to identify the predictors of malignancy. Aim of the study was to summarize published data about clinical risk factors for malignancy in patients with ITN and thereby provide more robust estimates of the effect of these risk factors. Sources comprised studies published through December 2012. Original articles that investigated clinical parameters as potential predictors of malignancy in ITN were identified. Two authors performed the data extraction independently. A meta-analysis of 19 relevant studies was conducted that included 3,494 patients with ITN according to FNAC. The pooled prevalence of malignancy was 28 % (95 % CI 23–33), 26 % in
females and 34 % in males. The pooled OR was 1.51 (95 % CI 1.2–1.83) for males and 0.68 (95 % CI 0.53–0.88) for females. Regarding the nodule’s size, the pooled OR was 2.10 (95 % CI 1.26–3.50) for nodules [4 cm in diameter. Analysis of the patient age as a risk factor was not feasible because of marked difference found between the studies. In patients with indeterminate thyroid nodules diagnosed at FNAC, the pooled rate of malignancy from 19 studies was 28 %. Patients that are male and have ITN greater than 4 cm in diameter should be considered at higher risk of cancer. Keywords Thyroid Cytology Age Gender Thy 3
Pierpaolo Trimboli and Giorgio Treglia share the first authorship. P. Trimboli Section of Endocrinology and Diabetology, Ospedale Israelitico, Rome, Italy
G. Nigri S. Valabrega Department of Medical and Surgical Sciences, Ospedale S. Andrea, Sapienza University, Rome, Italy
G. Treglia L. Giovanella Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
F. Romanelli Department of Experimental Medicine, Sapienza University, Rome, Italy
G. Treglia (&) L. Giovanella Department of Nuclear Medicine and PET/CT Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland e-mail: [email protected]
R. Sadeghi Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
L. Guidobaldi A. Crescenzi Section of Pathology, Ospedale Israelitico, Rome, Italy E. Saggiorato F. Orlandi Section of Endocrinology, Division of Internal Medicine, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
123
Endocrine (2014) 46:52–59
53
Introduction Fine-needle aspiration cytology (FNAC) is the primary diagno
Data Loading...
