Clotting state after cardioversion of atrial fibrillation: a haemostasis index could detect the relationship with the ar
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BioMed Central
Open Access
Original clinical investigation
Clotting state after cardioversion of atrial fibrillation: a haemostasis index could detect the relationship with the arrhythmia duration Eleni Hatzinikolaou-Kotsakou*1, Zafirios Kartasis2, Dimitrios Tziakas1, Dimitrios Stakos1, Athanasios Hotidis1, Georgios Chalikias1, Georgios Bourikas2 and Dimitrios I Hatseras1 Address: 1Academic Cardiology Department, Academic Hospital Dragana Alexandroupolis, Demokritus University of Thrace, Greece and 2Academic Hematology Department, Academic Hospital Dragana Alexandroupolis, Demokritus University of Thrace-Greece Email: Eleni Hatzinikolaou-Kotsakou* - [email protected]; Zafirios Kartasis - [email protected]; Dimitrios Tziakas - [email protected]; Dimitrios Stakos - [email protected]; Athanasios Hotidis - [email protected]; Georgios Chalikias - [email protected]; Georgios Bourikas - [email protected]; Dimitrios I Hatseras - [email protected] * Corresponding author
Published: 06 March 2005 Thrombosis Journal 2005, 3:2
doi:10.1186/1477-9560-3-2
Received: 19 October 2004 Accepted: 06 March 2005
This article is available from: http://www.thrombosisjournal.com/content/3/1/2 © 2005 Hatzinikolaou-Kotsakou et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Atrial fibrillationhaemostatic markers
Abstract Background: Fibrin D-dimer levels have been advocated as an useful clinical marker of thrombogenesis. Hypothesis: We hypothesized that i) there is a hyperclotting state after the return of atrial fibrillation to sinus rhythm, ii) the measurement of plasma D-Dimer levels might be a good screening tool of this clotting status, and iii) the duration of arrhythmia influences the haemostasis measured by plasma D-Dimer levels. Methods: Forty-two patients with atrial fibrillation undergoing cardioversion were divided into two groups: in Group A (n = 24,14 male, 56 ± 11 years) the duration of atrial fibrillation was 72 hours or more (142.7 ± 103.8 hours), in Group B (n = 18, 10 male, 61 ± 13 years) the duration of atrial fibrillation was less than 72 hours (25 ± 16 hours). Plasma fibrin D-dimer levels were measured by enzyme immunoassay before, and 36 hours after, cardioversion. The change of plasma D-dimer levels 36 hours after cardioversion was calculated as delta-D-dimer. Results: There were no significant differences in demographic, clinical, and echocardiographic data, and the success of cardioversion between the two groups. Compared to the control, the baseline D-dimer levels were significantly higher in both groups. The delta D-dimer levels were significantly higher in Group A than in Group B (p < 0.005). Furthermore, plasma D-dimer levels 36 hours after cardioversion (r = 0.52, p = 0.0016) and delta-D-dimer levels (r = 0.73, p < 0.0001) showed significant correlations with the d
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