Collision tumor of the thyroid: follicular variant of papillary carcinoma and squamous carcinoma
- PDF / 1,695,504 Bytes
- 6 Pages / 610 x 792 pts Page_size
- 54 Downloads / 193 Views
Open Access
Case report
Collision tumor of the thyroid: follicular variant of papillary carcinoma and squamous carcinoma Rohan R Walvekar1, Subhadra V Kane2 and Anil K D'Cruz*1 Address: 1Department of Head and Neck Surgery, Tata Memorial Hospital, Mumbai, India and 2Department of Pathology, Tata Memorial Hospital, Mumbai, India Email: Rohan R Walvekar - [email protected]; Subhadra V Kane - [email protected]; Anil K D'Cruz* - [email protected] * Corresponding author
Published: 19 September 2006 World Journal of Surgical Oncology 2006, 4:65
doi:10.1186/1477-7819-4-65
Received: 29 January 2006 Accepted: 19 September 2006
This article is available from: http://www.wjso.com/content/4/1/65 © 2006 Walvekar et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: Collision tumors of the thyroid gland are a rare entity. We present a case of a follicular variant of papillary carcinoma and squamous carcinoma in the thyroid. To the best of our knowledge, this is the first documentation of a collision tumor with a papillary carcinoma and a squamous carcinoma within the thyroid gland. The clinicopathological features and immunohistochemical profile are reported. The theories of origin, epidemiology and management are discussed with a literature review. Case presentation: A 65 year old woman presented with a large thyroid swelling of 10 years duration and with swellings on the back and scalp which were diagnosed to be a follicular variant of papillary thyroid carcinoma with metastasis. Clinical examination, radiology and endoscopy ruled out any other abnormality of the upper aerodigestive tract. The patient was treated surgically with a total thyroidectomy with central compartment clearance and bilateral selective neck dissections. The histopathology revealed a collision tumor with components of both a follicular variant of papillary carcinoma and a squamous carcinoma. Immunohistochemical analysis confirmed the independent origin of these two primary tumors. Adjuvant radio iodine therapy directed toward the follicular derived component of the thyroid tumor and external beam radiotherapy for the squamous component was planned. Conclusion: Collision tumors of the thyroid pose a diagnostic as well as therapeutic challenge. Metastasis from distant organs and contiguous primary tumors should be excluded. The origins of squamous cancer in the thyroid gland must be established to support the true evolution of a collision tumor and to plan treatment. Treatment for collision tumors should depend upon the combination of primary tumors involved and each component of the combination should be treated like an independent primary. The reporting of similar cases with longer follow up and will help define the epidemiology, biology and establish standardized protoc
Data Loading...
