Congenital Abnormalities and Preterm Birth Related to Maternal Illnesses During Pregnancy
This book provides the analysis of a uniquely large, population-based data set evaluating congenital anomalies as a consequence of maternal diseases. The possible adverse birth outcomes of babies born to mothers diagnosed with important diseases have not
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Nándor Ács · Ferenc G. Bánhidy · Andrew E. Czeizel
Congenital Abnormalities and Preterm Birth Related to Maternal Illnesses During Pregnancy
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Nándor Ács, MD, PhD Semmelweis University Second Department of Obstetrics and Gynecology Budapest 1082, Üll˝oi út 78/a Hungary [email protected]
Ferenc G. Bánhidy, MD, PhD Semmelweis University Second Department of Obstetrics and Gynecology Budapest 1082, Üll˝oi út 78/a Hungary [email protected]
Andrew E. Czeizel, MD, PhD, DSci Foundation of the Community Control of Hereditary Diseases Budapest 1026 Törökvész lejt˝o 32 Hungary [email protected]
ISBN 978-90-481-8619-8 e-ISBN 978-90-481-8620-4 DOI 10.1007/978-90-481-8620-4 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2010922898 © Springer Science+Business Media B.V. 2010 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Contents
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
xvii
Technical Notes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
xxi
Part I
The Study Population and Methods
1 The Hungarian Congenital Abnormality Registry (HCAR) . . . . . 1.1 Materials and Methods . . . . . . . . . . . . . . . . . . . . . . 1.2 The Data Base of the HCAR . . . . . . . . . . . . . . . . . . . 1.3 Quality Control of the HCAR . . . . . . . . . . . . . . . . . . 1.3.1 Study Populations and Samples . . . . . . . . . . . . . 1.3.2 Completeness of Notification . . . . . . . . . . . . . . 1.3.3 The Validity of CA-Diagnoses . . . . . . . . . . . . . 1.4 The Weaknesses of the HCAR . . . . . . . . . . . . . . . . . . 1.5 The Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA) . . . . . . . . . . . . . . . . . . . . 1.5.1 Study Groups . . . . . . . . . . . . . . . . . . . . . . 1.5.2 Collection of Exposure and Other Data . . . . . . . . . 1.5.3 Classification of CA-Groups . . . . . . . . . . . . . . 1.6 The Strengths and Weaknesses of the HCCSCA . . . . . . . . . 1.6.1 The Maternal Disease Itself . . . . . . . . . . . . . . . 1.6.2 Source of Exposure Information . . . . . . . . . . . . 1.6.3 The Time Factor . . . . . . . . . . . . . . . . . . . . . 1.6.4 Confounding Factors . . . . . . . . . . . . . . . . . . 1.6.5 The Evaluation of Possible Risk . . . . . . . . . . . . 1.7 Preterm Birth and Low Birth Weight Newborns . . . . . . . . . 1.7.1 Definitions . . . . . . . . . . . . . . . . . . . . . . . . 1.7.2 The Hungarian Data of Preterm Births . . . . . . . . . 1.8 The Data Set of the HCCSCA, 1980–1996 . . . . . . . . . . . 1.8.1 Maternal Diseases . . . . . . . . . .
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