Contemporary Survival in Heart Transplantation
The growing prevalence of heart failure in the worldwide population coupled with its high socioeconomic burden has escalated interest in any treatment modality that can dramatically affect the estimated 50% 5-year mortality commonly associated with heart
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Hampton A. Crimm, Nicholas R. Fiacco, and M. Casey Flanagan
Contents Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 406 Pre-transplant Variables . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 406 Transplant Variables . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 411 Post-Transplant . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 415 Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 419 Cross-References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 419 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 419
Abstract
The growing prevalence of heart failure in the worldwide population coupled with its high socioeconomic burden has escalated interest in any treatment modality that can dramatically affect the estimated 50% 5-year mortality commonly associated with heart failure. Cardiac
H. A. Crimm Cardiology Department, Walter Reed National Military Medical Center, Bethesda, MD, USA e-mail: [email protected] N. R. Fiacco Internal Medicine, Naval Medical Center Camp Lejeune, Camp Lejeune, NC, USA e-mail: nicholas.r.fi[email protected] M. C. Flanagan (*) Advanced Heart Failure and Transplant, INOVA Heart and Vascular Institute, Falls Church, VA, USA e-mail: michael.fl[email protected]
transplantation remains the definitive therapy for most patients with advanced heart failure and confers improvements in both survival and quality of life. Since the first cardiac transplant in 1967, the transplant community has been on a relentless pursuit to perfect this highly individualized and resource-heavy treatment modality. As a result of major advances in nearly every component of the heart transplant process, survival has incrementally improved in every decade, and most patients are surviving decades, and not months to years, after their transplant. This chapter examines the multitude of factors, from pre-transplant comorbidities, to surgical variables, to post-transplant management and comorbidities that have been proven to affect short-, intermediate-, and long-term survival in heart transplant recipients.
© This is a U.S. Government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2020 L. Bogar, A. Stempien-Otero (eds.), Contemporary Heart Transplantation, Organ and Tissue Transplantation, https://doi.org/10.1007/978-3-319-58054-8_35
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Keywords
Heart transplantat
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