Correction to: Analysis of FOXO3 Gene Polymorphisms Associated with Human Longevity
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Wolfgang Link Editor
FOXO Transcription Factors Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
FOXO Transcription Factors Methods and Protocols
Edited by
Wolfgang Link Instituto de Investigaciones Biomédicas “Alberto Sols” (CSIC-UAM), Madrid, Spain
Editor Wolfgang Link Instituto de Investigaciones Biome´dicas “Alberto Sols” (CSIC-UAM) Madrid, Spain
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-8899-0 ISBN 978-1-4939-8900-3 (eBook) https://doi.org/10.1007/978-1-4939-8900-3 Library of Congress Control Number: 2018959869 © Springer Science+Business Media, LLC, part of Springer Nature 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC, part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface FOXO transcription factors belong to the large family of forkhead proteins which is characterized by the presence of a ~100-residue forkhead (FKH) DNA-binding domain and bind as monomers to their consensus DNA-binding sites. FOXO proteins function as transcriptional regulators in the cell nucleus and activate the transcription of genes that are involved in numerous biologically relevant processes, such as metabolism, differentiation, proliferation, longevity, and apoptosis. FOXOs are key components of an evolutionary conserved pathway downstream of insulin and insulin-like growth factor receptors. FOXO proteins have been established as tumor suppressors and are known to determine longevity in a wide range of metazoans including humans. Recently, FOXO factors are receiving a
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