Current Hypotheses and Research Milestones in Alzheimer's Disease
Almost four decades of innovative and intensive research on Alzheimer's disease (AD) have brought major advances in our understanding of its pathogenesis, while improving tools for diagnosis and developing strategies for its treatment. This research has h
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Ricardo B. Maccioni
•
George Perry
Editors
Current Hypotheses and Research Milestones in Alzheimer’s Disease
Editors Ricardo B. Maccioni Mind/Brain Program of the International Center of Biomedicine and University of Chile Santiago, Chile and University of Miami School of Medicine Miami, Florida USA
George Perry College of Sciences University of Texas at San Antonio San Antonio, Texas 78249-0661 USA
ISBN: 978-0-387-87994-9 e-ISBN: 978-0-387-87995-6 DOI: 10.1007/978-0-387-87995-6 Library of Congress Control Number: 2008942056 © Springer Science+Business Media, LLC 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper springer.com
Preface
Almost four decades of increasingly faster and more intensive research on Alzheimer’s disease (AD) have brought major advances in our understanding of its pathogenesis, improved tools for diagnosis, and strategies for its treatment. This research has shown us that exploring the factors leading to cognitive impairment is mired with elusive goals and unexpected leads toward the mechanisms responsible for this pathology. This complex, yet fruitful process has allowed us to contribute to building a solid foundation of knowledge in the neurosciences, to tackle the biological basis of AD, and related neurological disorders. This book contains 20 seminal chapters by authors with different views that in a multidisciplinary approach focus on the main issues of neuroanatomical, neuropathological, neuropsychological, neurological, and molecular biological aspects of AD. The idea for this collection arose during the preparation of the proceedings for the International Summit Meeting “Current Hypotheses on Alzheimer’s Disease” and was warmly received by the prestigious editorial house Springer Verlag. The book you now have the opportunity to read is the result of substantial efforts by many people, including the editors and their collaborators. The main goal has been to summarize in several chapters the contributions presented in an international gathering held November 22–25, 2007 at the Conference Town in Reñaca, Viña del Mar, Chile, attended by some of the leading scientists in the field. Presentations focused on milestones in research that have illuminated Alzheimer’s investigations during the past decades and will continue at the forefront. This prolific event was organized by the Intern
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