Damage-Associated Molecular Patterns in Human Diseases Volume 1: Inj
This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunolog
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Damage-Associated Molecular Patterns in Human Diseases
Walter Gottlieb Land
Damage-Associated Molecular Patterns in Human Diseases Volume 1: Injury-Induced Innate Immune Responses
Walter Gottlieb Land University of Strasbourg Molecular ImmunoRheumatology, Laboratory of Excellence Transplantex Strasbourg France
ISBN 978-3-319-78654-4 ISBN 978-3-319-78655-1 (eBook) https://doi.org/10.1007/978-3-319-78655-1 Library of Congress Control Number: 2018945903 © Springer International Publishing AG, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer International Publishing AG part of Springer Nature. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Foreword
In 1994, roughly 10 years after I first met Walter Land, at his institution, the Division of Transplant Surgery at the University of Munich, a prospective study in renal transplantation was performed, using a single shot of a perioperatively given antioxidant. At that time, nobody would have thought that 8 years later follow-up data from this study would revolutionize the perception of immunology in transplant medicine. When in 2002 his damage hypothesis was formulated, I was in the lucky position as deputy director of his institution, to prove—for the first time— the existence of the heat shock protein 72 in renal and pancreatic transplants [1], a year later interpreted and published by Walter Land as an example of damageassociated molecular patterns (DAMPs). It also fills me with pride, having been witness to the creation of the term „DAMPs“, at a meeting in Pegnitz in 2003, by Polly Matzinger and Walter Land, two pioneers in the field of innate immunity, who also coined the danger/injury hypothesis in 1994. Since then, Walter has been continuously committed to increasi
