Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window
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ARTICLE
Cite as Nano-Micro Lett. (2020) 12:38 Received: 28 November 2019 Accepted: 26 December 2019 © The Author(s) 2020
https://doi.org/10.1007/s40820-020-0378-6
Deep‑Tissue Photothermal Therapy Using Laser Illumination at NIR‑IIa Window Xunzhi Wu1, Yongkuan Suo1, Hui Shi1, Ruiqi Liu1, Fengxia Wu1, Tingzhong Wang2, Lina Ma3, Hongguang Liu1 *, Zhen Cheng4 * * Hongguang Liu, [email protected]; Zhen Cheng, [email protected] Institute of Molecular Medicine, College of Life and Health Sciences, Northeastern University, Shenyang 110000, People’s Republic of China 2 Department of Neurosurgery, The Fourth Affiliated Hospital of China Medical University, Shenyang 110000, People’s Republic of China 3 Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130000, People’s Republic of China 1
4
Molecular Imaging Program at Stanford, Stanford University, Palo Alto, CA 94301, USA
HIGHLIGHTS
• The laser of 1275 nm exhibited excellent ablation of tumors with 5-mm porcine muscle tissue blocking, while 808 nm laser failed.
A B S T R AC T P h o t o t h e r m a l therapy (PTT) using near-infrared
(NIR) light for tumor treatment has triggered extensive attentions because of its advantages of noninvasion and convenience. The current research on PTT usually uses lasers in the first NIR window (NIR-I; 700–900 nm) as irradiation source. However,
NIR-I/NIR-IIa porcine muscle
Relative tumor volume
• Polyethylene glycol-stabilized copper sulfide nanoparticles with similar absorption efficiency at wavelength of 808 and 1275 nm were employed to compare the potential of these two lasers in deep-tissue photothermal therapy.
the second NIR window (NIR-II;
20 15
808 nm 1275 nm
10 5 0 0 2 4 6 8 10 12 14 16 Time (d)
1000–1700 nm) especially NIRIIa window (1300–1400 nm) is considered much more promising in diagnosis and treatment as its superiority in penetration depth and maximum permissible exposure over NIR-I window. Hereby, we propose the use of laser excitation at 1275 nm, which is approved by Food and Drug Administration for physical therapy, as an attractive technique for PTT to balance of tissue absorption and scattering with water absorption. Specifically, CuS-PEG nanoparticles with similar absorption values at 1275 and 808 nm, a conventional NIR-I window for PTT, were synthesized as PTT agents and a comparison platform, to explore the potential of 1275 and 808 nm lasers for PTT, especially in deep-tissue settings. The results showed that 1275 nm laser was practicable in PTT. It exhibited much more desirable outcomes in cell ablation in vitro and deep-tissue antitumor capabilities in vivo compared to that of 808 nm laser. NIR-IIa laser illumination is superior to NIR-I laser for deep-tissue PTT, and shows high potential to improve the PTT outcome. KEYWORDS Photothermal therapy; Deep-tissue; NIR-IIa; 1275 nm laser; Molecular imaging
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1 Introduction Photothermal therapy (PTT) is a novel therapeutic method for treatment of diseases especially
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