Delirium in COVID-19: epidemiology and clinical correlations in a large group of patients admitted to an academic hospit
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ORIGINAL ARTICLE
Delirium in COVID‑19: epidemiology and clinical correlations in a large group of patients admitted to an academic hospital Andrea Ticinesi1 · Nicoletta Cerundolo1 · Alberto Parise1 · Antonio Nouvenne1 · Beatrice Prati1 · Angela Guerra2 · Fulvio Lauretani1,2 · Marcello Maggio1,2 · Tiziana Meschi1,2 Received: 9 July 2020 / Accepted: 26 August 2020 © The Author(s) 2020
Abstract Background Delirium incidence and clinical correlates in coronavirus disease-19 (COVID-19) pneumonia are still poorly investigated. Aim To describe the epidemiology of delirium in patients hospitalized for suspect COVID-19 pneumonia during the pandemic peak in an academic hospital of Northern Italy, identify its clinical correlations and evaluate the association with mortality. Methods The clinical records of 852 patients admitted for suspect COVID-19 pneumonia, defined as respiratory symptoms or fever or certain history of contact with COVID-19 patients, plus chest CT imaging compatible with alveolar-interstitial pneumonia, were retrospectively analyzed. Delirium was defined after careful revision of daily clinical reports in accordance with the Confusion Assessment Method criteria. Data on age, clinical presentation, comorbidities, drugs, baseline lab tests and outcome were collected. The factors associated with delirium, and the association of delirium with mortality, were evaluated through binary logistic regression models. Results Ninety-four patients (11%) developed delirium during stay. They were older (median age 82, interquartile range, IQR 78–89, vs 75, IQR 63–84, p
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