Designed fabrication of mesoporous silica-templated self-assembled theranostic nanomedicines
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signed fabrication of mesoporous silica-templated self-assembled theranostic nanomedicines Yang Du
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, Zheng Chen , Ji Young Lee , Peihua Lin , Fan Xia , Yunan Guan , 1 1,2,3* Fangyuan Li & Daishun Ling
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Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Key Laboratory of Biomedical Engineering of the Ministry of Education, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310027, China; 3 Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; 4 Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, 5
Hangzhou 310009, China; Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province, Hangzhou 310009, China Received August 17, 2020; accepted September 7, 2020; published online December 1, 2020
Theranostic nanosystems that integrate diagnosis and therapy have garnered increasing attention for personalized medicine. The integration of the versatile nanoparticles to fabricate self-assembled theranostic nanomedicines becomes increasingly important in current medical research. Mesoporous silica nanoparticles (MSN) with their highly attractive physicochemical properties and favorable morphological attributes represent ideal templates for the controlled assembly and integration of functional nanomaterials to fabricate self-assembled theranostic nanomedicines. The rationally designed combination strategy and heterostructure will improve the overall bioavailability and preserve the unique property of each nanocomponent. In this review, the cutting-edge strategies for the designed fabrication of MSN-templated self-assembled nanomedicines are summarized. We categorize MSN-based nanomedicines by their unique heterostructures, including core-shell, yolk-shell, core-satellite, heterodimer and core-shell-satellite structures, and discuss the controlled assembly approaches as well as the intriguing applications for disease theranostics. Finally, a perspective on the challenges in the clinical translation of self-assembled theranostic nanomedicines is highlighted. self-assembly, theranostics, heterostructure, mesoporous silica, nanomedicines Citation:
Du Y, Chen Z, Lee JY, Lin P, Xia F, Guan Y, Li F, Ling D. Designed fabrication of mesoporous silica-templated self-assembled theranostic nanomedicines. Sci China Chem, 2021, , https://doi.org/10.1007/s11426-020-9869-4
1 Introduction The past decades have witnessed significant nanotechnological advances in biomedical applications [1]. The functional nanomaterials with unique electrical, thermal, optical, catalytic and magnetic properties are extensively used to serve as drug delivery vehicles, imaging probes as well as therapeutic *Corresponding authors (email: [email protected])
agents for efficient medical diagnosis, monitoring and treatment of diseases [1–3]. For example, do
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