Development of a technique for MRI gold-standard direct volumetric measurement of complex joint effusion, and validation
- PDF / 1,477,270 Bytes
- 7 Pages / 595.276 x 790.866 pts Page_size
- 62 Downloads / 179 Views
SCIENTIFIC ARTICLE
Development of a technique for MRI gold-standard direct volumetric measurement of complex joint effusion, and validation at the hip Vanessa Quinn-Laurin 1 & Geoffrey P. Bostick 2 & Bashiar Thejeel 1 & Ramin Mandegaran 3 & Kieran J. D. Steer 1 & Robert G. W. Lambert 1,4 & Jacob L. Jaremko 1,4 Received: 23 June 2020 / Revised: 23 September 2020 / Accepted: 24 September 2020 # ISS 2020
Abstract Objective Accurate joint fluid quantification on MRI cannot simply rely on measuring the maximum fluid depth or using an ellipsoid approximation as this does not fully characterize the complex shape of a fluid-filled joint. As per the Outcome Measurement in Rheumatology (OMERACT) filter, we sought to evaluate the feasibility, reliability, and validity of a semiautomated supervised technique to quantify hip effusion volume. Materials and methods Ninety-three hip osteoarthritis patients were imaged with coronal short TI inversion recovery (STIR) and sagittal intermediate weighted fat-suppressed (IWFS) sequences at two time points (Fig. 1). Volumetric quantitative measurement (VQM) of joint fluid and measurement of the largest femoral neck fluid thickness (FTM) was performed using the custom MATLAB software. Self-reported Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and clinical measures of pain, stiffness, and function were recorded. Results Inter-observer reliability was significantly higher for VQM than FTM (ICC = 0.96 vs. 0.85, p < 0.05). VQM and FTM correlated moderately (r = 0.76, p < 0.0001). There was significantly more articular fluid in symptomatic than asymptomatic hips at baseline (mean = 9.8 vs. 5.9 mL). Volumetric quantitative measurement generally displayed more frequent and stronger correlations to clinical parameters than FTM. Volumetric quantitative measurement required 3.9 min/hip vs. < 1 min/hip for femoral neck fluid thickness. Conclusion Volumetric quantitative measurement of joint effusion can serve as an MRI gold-standard, could apply to other joints and collections, and is highly suited to future automation. Keywords Osteoarthritis . Joint effusion . Hip joints . Volumetric quantification
Introduction Osteoarthritis (OA) is a common and burdensome disease [1], historically with little treatment available to limit progression [2–6]. Inflammation is a key part of * Jacob L. Jaremko [email protected] 1
Department of Radiology, University of Alberta Hospital & Stollery Children’s Hospital, 2J2.00 WC Mackenzie Health Sciences Centre, University of Alberta, 8440 112 St. NW, Edmonton, AB T6G 2R7, Canada
2
Department of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada
3
Central Alberta Medical Imaging Services, Red Deer, Canada
4
Medical Imaging Consultants, Edmonton, Canada
OA pathophysiology, which is increasingly a target for therapy [7–9], and can manifest as synovitis and joint effusion. Measuring joint effusions is problematic at the hip in particular. Patients with hip OA are often only investigated with
Data Loading...
