Development of Novel Vaccines Skills, Knowledge and Translational Te
“Development of novel vaccines” gives an overview of the tasks in basic research leading to the final product – the vaccine and its applications, belonging to the most complex biologics in the pharmaceutical field. Distinct from most textbooks in the vacc
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Alexander von Gabain • Christoph Klade Editors
Development of Novel Vaccines Skills, Knowledge and Translational Technologies
Editors Alexander von Gabain Intercell AG Vienna, Austria
Christoph Klade Intercell AG Vienna, Austria
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machines or similar means, and storage in data banks. Product Liability: The publisher can give no guarantee for all the information contained in this book. This does also refer to information about drug dosage and application thereof. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. # 2012 Springer-Verlag Wien SpringerWienNewYork is a part of Springer Science þ Business Media springer.at Typesetting: SPi, Pondicherry, India Printed on acid-free and chlorine-free bleached paper SPIN: 80018701 With 70 Figures Library of Congress Control Number: 2012934577 Additional material to this book can be downloaded from http://extra.springer.com. ISBN 978-3-7091-0708-9 DOI 10.1007/978-3-7091-0709-6 SpringerWienNewYork
e-ISBN 978-3-7091-0709-6
Preface
Vaccination is the single most important medical intervention having saved more lives than any other. As such it is an outstanding and amazing achievement of the human mind, and yet admittedly vaccinology for the longest time has been driven purely empirically. In the last 3 decades, the advent of novel scientific disciplines including molecular microbiology, molecular genetics, and molecular immunology but also novel manufacturing technologies has changed the approach to vaccine development entirely. For the first time, we can decipher the detailed structures and even the attack programs of our foes, and insights into the mechanisms of protective immunity on the cellular and molecular level allow rational design of vaccine candidates. But the impact of this recent scientific and technology progress extends even further into the development and manufacturing of vaccines allowing for higher purity, more detailed characterization, and, as the ultimate consequence, improved safety. Finally, also clinical evaluation has been elevated from mere efficacy testing to a complex reading of immune response applying an everincreasing battery of surrogate parameters and correlates of protection. This book aims to give overview and insight into the by now increasingly rational approach to vaccine discovery, design, and development. As such it provides state-of-the-art contributions by some of the leading experts within academia, biotech, pharma industry, and regulatory agencies. Our overruling motivation has been to collect and
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