Development of tannic acid-enriched materials modified by poly(ethylene glycol) for potential applications as wound dres
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ORIGINAL RESEARCH
Development of tannic acid‑enriched materials modified by poly(ethylene glycol) for potential applications as wound dressing Beata Kaczmarek1 · Olha Mazur1 · Oliwia Miłek2 · Marta Michalska‑Sionkowska3 · Anna M. Osyczka2 · Konrad Kleszczyński4 Received: 6 July 2020 / Accepted: 8 September 2020 © The Author(s) 2020
Abstract The interests in the biomedical impact of tannic acid (TA) targeting production of various types of biomaterials, such as digital microfluids, chemical sensors, wound dressings, or bioimplants constantly increase. Despite the significant disadvantage of materials obtained from natural-based compounds and their low stability and fragility, therefore, there is an imperative need to improve materials properties by addition of stabilizing formulas. In this study, we performed assessments of thin films over TA proposed as a cross-linker to be used in combination with polymeric matrix based on chitosan (CTS), i.e. CTS/ TA at 80:20 or CTS/TA at 50:50 and poly(ethylene glycol) (PEG) at the concentration of 10% or 20%. We evaluated their mechanical parameters as well as the cytotoxicity assay for human bone marrow mesenchymal stem cells, human melanotic melanoma (MNT-1), and human osteosarcoma (Saos-2). The results revealed significant differences in dose-dependent of PEG regarding the maximum tensile strength (σmax) or impact on the metabolic activity of tissue culture plastic. We observed that PEG improved mechanical parameters prominently, decreased the hemolysis rate, and did not affect cell viability negatively. Enclosed data, confirmed also by our previous reports, will undoubtedly pave the path for the future application of tannic acid-based biomaterials to treat wound healing. Keywords Tannic acid · Poly(ethylene glycol) · Regeneration · Wound dressing · Proliferation
Introduction Polymers have multiple capabilities to be used in targeting production of various types of biomaterials, for instance, digital microfluids, chemical sensors, wound dressings, or bioimplants (Jayaprakash et al. 2015; Kang et al. 2011; * Konrad Kleszczyński [email protected] 1
Department of Biomaterials and Cosmetics Chemistry, Faculty of Chemistry, Nicolaus Copernicus University, Gagarina 7, 87‑100 Toruń, Poland
2
Department of Biology and Cell Imaging, Faculty of Biology, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 7, 30‑387 Kraków, Poland
3
Department of Environmental Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, Nicolaus Copernicus University, Lwowska 1, 87‑100 Toruń, Poland
4
Department of Dermatology, University of Münster, Von‑Esmarch‑Str. 58, 48149 Münster, Germany
Sarvothaman et al. 2015). They are known to possess excellent film-forming abilities and are miscible with different types of synthetic and natural compounds (Lewandowska et al. 2016). Biopolymers exert high biocompatibility and show adverse effects, thereby they are commonly applied to obtain wide types of materials f
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