Diabetes & C-Peptide Scientific and Clinical Aspects
In Diabetes & C-Peptide: Scientific and Clinical Aspects, a renowned group of leading researchers and physicians offers a comprehensive overview of the role of C-Peptide in type 1 diabetes. The book is organized in five sections. An Introductory secti
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Anders A.F. Sima Editor
Diabetes & C-Peptide Scientific and Clinical Aspects
Editor Anders A.F. Sima, MD, PhD, FRCP(C) Professor, Departments of Pathology and Neurology Wayne State University Detroit, MI, USA [email protected]
ISBN 978-1-61779-390-5 e-ISBN 978-1-61779-391-2 DOI 10.1007/978-1-61779-391-2 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011939746 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Foreword
Type 1 diabetes has in recent years shown an alarming increase in incidence, particularly in heavily populated regions of the globe, occurring at steadily younger ages. This increase in incidence of type 1 diabetes will likely be paralleled by a similar increase in the frequency of the disorder’s debilitating secondary complications. Since its discovery, C-peptide has evolved from a non-bioactive marker of b-cell function to a highly significant multifunctional hormone in the pathobiology of diabetes and its complications. The wealth of information that has appeared over the last decade and a half is reviewed in depth in this volume. This review provides current insights into the multiple physiological functions of C-peptide, its pathophysiological role in the development of chronic complications and ultimately the significance of its replacement in the prevention and treatment of these complications in patients with type 1 diabetes. The chapters are authored by the leading investigators in the field. This volume of Contemporary Diabetes provides the first comprehensive collection of current, detailed and critical reviews on C-peptide biology. It is highly recommended to clinicians, diabetologists, residents, basic scientists, and students who are seeking insights into C-peptide and the rapidly growing biology surrounding this versatile and highly relevant hormone.
Ann Arbor, MI, USA
Eva L. Feldman, MD, PhD
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Preface
It is well known that C-peptide, the connecting peptide of the proinsulin molecule, is an important part in the biosynthesis of insulin in that it facilitates its correct folding. Following the cleavage of proinsulin into ins
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