Diagnostic value of retrospectively fused 64 CuCl 2 PET/MRI in biochemical relapse of prostate cancer: comparison with f
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PELVIS
Diagnostic value of retrospectively fused 64CuCl2 PET/MRI in biochemical relapse of prostate cancer: comparison with fused 18 F‑Choline PET/MRI, 64CuCl2 PET/CT, 18F‑Choline PET/CT, and mpMRI Francesco Paparo1 · Alice Peirano2 · João Matos2 · Lorenzo Bacigalupo1 · Umberto Rossi3 · Ilaria Mussetto1 · Gianluca Bottoni4 · Martina Ugolini5 · Carlo Introini6 · Filippo Grillo Ruggieri7 · Gian Andrea Rollandi1 · Arnoldo Piccardo4
© Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose To assess the diagnostic value of retrospectively fused PET/MRI by comparing the detection rates (DRs) of fused 64 CuCl2 PET/MRI vs. fused 18F-Choline PET/MRI in patients with suspected prostatic cancer (PCa) recurrence. The secondary objective was to compare the DRs of fused PET/MRI vs. those of the separate imaging modalities. Methods We retrospectively evaluated 50 PCa patients with biochemical relapse after radical prostatectomy (RP) or radiotherapy (RT). All patients underwent 64CuCl2 PET/CT, 18F-Choline PET/CT, and multiparametric magnetic resonance imaging (mpMRI) within 15 days. Fused 64CuCl2-PET/MRI and fused 18F-Choline PET/MRI images were obtained by retrospective co-registration of MRI and PET images. Experienced readers interpreted the images, and the DRs of each imaging modality were assessed. Results In the patient-based analysis, overall DRs of fused 64CuCl2 PET/MRI, fused 18F-Choline PET/MRI, 64CuCl2 PET/ CT, 18F-Choline PET/CT, and mpMRI were 88%, 68%, 82%, 56%, and 74%, respectively. In the lesion-based analysis, overall DRs of fused 64CuCl2 PET/MRI, fused 18F-Choline PET/MRI, 64CuCl2 PET/CT, 18 F-Choline PET/CT, and mpMRI were 95%, 66%, 87%, 58%, and 71%, respectively. Conclusions Retrospectively fused PET/MRI is able to overcome the limitations of the separate interpretation of the individual imaging modalities. Fused 64CuCl2 PET/MRI provided the highest diagnostic performance in the detection of PCa local relapse. Keywords Prostate · Cancer · Recurrence · PET · Magnetic resonance imaging
Francesco Paparo and Alice Peirano contributed equally to the manuscript. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00261-020-02591-7) contains supplementary material, which is available to authorized users. * João Matos [email protected] 1
Unit of Radiology, Department of Diagnostic Imaging, E.O. Galliera Hospital, Genoa, Italy
2
DISSAL – Department of Health Sciences, University of Genoa, Via Antonio Pastore, 1, 16132 Genoa, GE, Italy
3
Unit of Interventional Radiology, Department of Diagnostic Imaging, E.O. Galliera Hospital, Genoa, Italy
Abbreviations PCa Prostate cancer RP Radical prostatectomy RT Radiotherapy mpMRI Multiparametric magnetic resonance imaging DWI Diffusion-weighted imaging DCE Dynamic contrast-enhanced 4
Unit of Nuclear Medicine, Department of Diagnostic Imaging, E.O. Galliera Hospital, Genoa, Italy
5
Medical Physics Unit, Department of Diagnostic Imaging, E.O. Galliera H
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