Dipyrone
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Dipyrone Rhinoconjunctivitis: case report A 49-year-old man developed rhinoconjunctivitis after taking dipyrone. The man presented to his medical practitioner having developed ocular and nasal symptoms of rhinitis and conjunctivitis 30 to 60 minutes after taking dipyrone [dosage, route of administration, therapeutic indication and outcome not clearly stated]. Skin prick and intradermal tests were performed with dipyrone [Novalgina] and were negative. An oral challenge test (OCT) was also performed using dipyrone [Novalgina] drops 500 mg/mL. The dipyrone test was negative on spirometry and cutaneous parameters but he developed rhinorrhoea, nasal congestion and conjunctivitis, and a significant increase in nasal resistance (R= +120) with sudden latency time of symptom onset (30 min) after his first dose. He showed no reaction to an aspirin challenge. Author comment: "In our patient, the negative responses to skin tests in the presence of naso-ocular symptoms and increase in R= +120 on [anterior rhinomanometry] indicate that a [dipyrone] metabolite may induce the IgE-mediated reaction." Di Leo E, et al. Immediate rhinoconjunctivitis induced by metamizole: an allergic 803043944 reaction? Allergy 65: 1070-1, No. 8, Aug 2010 - Italy
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Reactions 27 Nov 2010 No. 1329
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