Dissociable fronto-striatal functional networks predict choice impulsivity
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ORIGINAL ARTICLE
Dissociable fronto‑striatal functional networks predict choice impulsivity Qiang Wang1,2,3 · Chenyu Lv4 · Qinghua He4,5 · Gui Xue6 Received: 18 November 2019 / Accepted: 7 August 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Fronto-striatal structural connectivity is associated with choice impulsivity. Yet, to date, whether distinct fronto-striatal functional coupling associates with impulsive choices are largely unknown. Using seed-based resting-state functional MRI (rsfMRI) combined with multivariate pattern analysis (MVPA), the present study aimed to explore the predictions of dissociable frontal–striatal functional connectivity on choice impulsivity in a relatively large sample (N = 429). Adaptive delay-discounting task was utilized to assess choice impulsivity and the striatum was further divided into three subregions including the nucleus accumbens (NAcc), caudate, and putamen. Results revealed that both the functional coupling between the NAcc and the limbic/dorsolateral prefrontal cortex, and between the caudate and the dorsal prefrontal cortex, including the dorsomedial prefrontal cortex (DMPFC), successfully predicted the delay-discounting rate. However, such pattern was not observed in the putamen-prefrontal functional connectivity. These findings suggest fronto-striatal-dependent neural mechanisms of choice impulsivity and further provide a better understanding of the contributions of striatum subregions and their functional connectivities with different areas of prefrontal cortex upon inter-temporal choice. Keywords Inter-temporal choice · Multivariate pattern analysis · Prefrontal cortex · Choice impulsivity · Striatum · Functional connectivity
Introduction Impulsivity refers to the tendency to engage in behavior that involves rashness, a lack of foresight or planning, or as behavior that occurs without reflection or careful deliberation (Dawe et al. 2004). As one of the most important Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00429-020-02128-0) contains supplementary material, which is available to authorized users.
sub-component of impulsivity, choice impulsivity exists ubiquitously in our everyday life and preschool children who exhibit low choice impulsivity are more prone to develop into cognitively and socially competent adolescents, manifesting higher scholastic performance and extraordinary ability to coping with frustration and stress (Mischel et al. 1989). In general, the delay-discounting task is behaviorally and objectively utilized to assess and measure impulsivity especially impulsive choice in the laboratory environment (Bari
* Qiang Wang [email protected]
3
Tianjin Social Science Laboratory of Students’ Mental Development and Learning, Tianjin 300387, China
* Qinghua He [email protected]
4
Faculty of Psychology, Southwest University, Chongqing 400715, China
* Gui Xue [email protected]
5
CAS Key Laboratory of Mental Health, Institute of Psychology, Beijin
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