Drusen characteristics of type 2 macular neovascularization in age-related macular degeneration
- PDF / 1,321,415 Bytes
- 7 Pages / 595.276 x 790.866 pts Page_size
- 5 Downloads / 229 Views
RESEARCH ARTICLE
Open Access
Drusen characteristics of type 2 macular neovascularization in age-related macular degeneration Daniel Ahmed1,2†, Martin Stattin1,2†, Anna-Maria Haas1,2, Alexandra Graf3, Katharina Krepler1,2 and Siamak Ansari-Shahrezaei1,2,4*
Abstract Background: Type 2 macular neovascularization (MNV) is supposed to be a rare condition in age-related macular degeneration (AMD). The main purpose of this study was to assess accompanying factors of type 2 MNV in AMD. Methods: Retrospective data analysis of eyes previously diagnosed with neovascular AMD in a tertiary eye care center (Medical Retina Unit, Rudolf Foundation Hospital, Vienna, Austria) between June 2008 and December 2017. Drusen subtypes, fibrosis, atrophy and subfoveal choroidal thickness (SFCT) of both eyes in patients with type 2 MNV lesions were categorized based on multimodal imaging. Results: Type 2 MNV was diagnosed in 27 (3.2%) of 835 eyes (749 patients). Drusen characteristics in type 2 MNV were observed as followed: drusen < 63 μm in 2 eyes (7.4%), drusen ≥63 μm in 10 eyes (37%), subretinal drusenoid deposits (SDD) in 8 eyes (29.6%), cuticular drusen in 2 eye (7.4%) and no drusen were evident in 10 eyes (37%). Drusen distribution in 23 fellow eyes was detected as followed: drusen < 63 μm in 2 eyes (8.7%), drusen ≥63 μm in 9 eyes (39.1%), SDD in 5 eyes (21.7%), cuticular drusen in 1 eye (4.3%) and no drusen were evident in 9 eyes (39.1%). Mean SFCT was 140 ± 49 μm in affected eyes and 152 ± 41 μm in the fellow eyes. Patients with drusen or SDD were significantly younger (mean 70.88 ± 6.85, p = 0.04) than patients without deposits (mean 77.40 ± 5.74). Conclusions: Type 2 MNV remains a rare entity in AMD. It was frequently seen in the absence of drusen, a hallmark of AMD. These findings contribute to the heterogeneity of phenotypes related to pure type 2 lesions. Keywords: Age-related macular degeneration, Type 2 macular neovascularization, Drusen, Subretinal drusenoid deposits
Background Early and intermediate age-related macular degeneration (AMD) are defined by the existence of drusen, pigmentary abnormalities or extrafoveal atrophy [1, 2]. Various types of drusen such as soft, hard, cuticular or subretinal * Correspondence: [email protected]; [email protected] † Daniel Ahmed and Martin Stattin contributed equally to this work. 1 Karl Landsteiner Institute for Retinal Research and Imaging, Vienna, Austria 2 Department of Ophthalmology, Rudolf Foundation Hospital, Juchgasse 25, 1030 Vienna, Austria Full list of author information is available at the end of the article
drusenoid deposits (SDD) – also referred to as reticular pseudodrusen - confirm with the diagnosis of AMD [3]. Drusen are typically located between the retinal pigment epithelium (RPE) and the Bruch’s membrane, whereas SDD are found in the subretinal space [4–7]. Small drusen (< 63 μm) are considered normal aging changes, while medium (≥63 - < 125 μm) to large drusen (≥125 μm) are associated with an increased risk for the developm
Data Loading...
