Effect of obesity reduction on preservation of heart function and attenuation of left ventricular remodeling, oxidative
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RESEARCH
Open Access
Effect of obesity reduction on preservation of heart function and attenuation of left ventricular remodeling, oxidative stress and inflammation in obese mice Hui-Ting Wang1, Chu-Feng Liu1†, Tzu-Hsien Tsai2, Yung-Lung Chen2, Hsueh-Wen Chang3, Ching-Yen Tsai4, Steve Leu5, Yen-Yi Zhen5, Han-Tan Chai2, Sheng-Ying Chung2, Sarah Chua2, Chia-Hung Yen6* and Hon-Kan Yip2,5*
Abstract Background: Obesity is an important cardiovascular risk factor. This study tested the effect of obesity reduction on preserving left ventricular ejection fraction (LVEF) and attenuating inflammation, oxidative stress and LV remodeling in obese mice. Methods and results: Eight-week-old C57BL/6 J mice (n=24) were equally divided into control (fed a control diet for 22 weeks), obesity (high-fat diet, 22 weeks), and obese reduction (OR) (high-fat diet, 14 weeks; then control diet, 8 weeks). Animals were sacrificed at post 22-week high-fat diet and the LV myocardium collected. Heart weight, body weight, abdominal-fat weight, total cholesterol level and fasting blood glucose were higher in obesity than in control and OR (all p
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