Effect of physical activity promotion on adiponectin, leptin and other inflammatory markers in prediabetes: a systematic
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ORIGINAL ARTICLE
Effect of physical activity promotion on adiponectin, leptin and other inflammatory markers in prediabetes: a systematic review and meta‑analysis of randomized controlled trials Radhika Aditya Jadhav1 · G. Arun Maiya1 · Aditi Hombali2 · Shashikiran Umakanth3 · K. N. Shivashankar4 Received: 1 August 2020 / Accepted: 21 October 2020 © The Author(s) 2020
Abstract Aims Inflammatory stage in prediabetes is associated with increase in level of adipokines and pro-inflammatory cytokines. Physical activity promotion considered as a first-line therapeutic strategy to treat prediabetes. We have conducted the systematic review and meta-analysis to strengthen the evidence on the impact of physical activity promotion on inflammatory markers in prediabetes. Methods Studies were identified using electronic search and manual search techniques by choosing keywords for prediabetes, physical activity and inflammatory marker. Randomized controlled trials on individuals diagnosed with prediabetes and provided intervention in the form of physical activity were included in this review. Adiponectin, leptin, C-reactive protein, interleukin-6 and tumour necrosis factor-α were the considered outcome measures. Results Our search retrieved 1,688 citations, 31 full-text articles assessed for eligibility of inclusion. Nine studies satisfied the pre-specified criteria for inclusion. Meta-analysis found that physical activity with or without dietary or lifestyle modification reduces level of leptin (MD−2.11 ng/mL, 95% CI −3.81 – −0.42) and interleukin-6 (MD −0.15 pg/mL, 95% CI −0.25–−0.04). It has no effect on level of adiponectin (MD 0.26 µg/mL, 95% CI −0.42– 0.93), C-reactive protein (MD −0.05 mg/L, 95% CI −0.33–0.23) and tumour necrosis factor-α (MD 0.67 pg/mL, 95% CI −2.56–3.89). Conclusions This review suggests that physical activity promotion with dietary and lifestyle modification may reduce the level of leptin and interleukin-6 but are uncertain if there is any effect on levels of adiponectin, C-reactive protein and tumour necrosis factor-α in the individuals with prediabetes. Keywords Diabetes · Lifestyle · Inflammation · Cytokines · Adipokines Managed by Antonio Secchi. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00592-020-01626-1) contains supplementary material, which is available to authorized users. * G. Arun Maiya [email protected]; [email protected] 1
Department of Physiotherapy, Centre for Diabetic Foot Care and Research, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India
2
Independent Systematic Reviewer, Luton, Bedfordshire, UK
3
Department of Medicine, Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India
4
Department of Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India
Abbreviations T2DM Type 2 diabetes mellitus ADA American Diabetes Association WHO W
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