Effects of different energy density low-level laser therapies for temporomandibular joint disorders patients: a systemat
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ORIGINAL ARTICLE
Effects of different energy density low-level laser therapies for temporomandibular joint disorders patients: a systematic review and network meta-analysis of parallel randomized controlled trials Guoyi Jing 1 & Yatao Zhao 2 & Fangrui Dong 1 & Pengfei Zhang 1 & Hui Ren 1 & Jingying Liu 1 & Yang Liu 1 & Caiyun Yu 1 & Jingjing Hu 1 & Guangjie Bao 3 & Hong Kang 1 Received: 2 July 2020 / Accepted: 13 November 2020 # Springer-Verlag London Ltd., part of Springer Nature 2020
Abstract Purpose To compare the effects of different energy density LLLT on TMD patients’ pain reduction. Methods Reviewers searched RCTs published in Embase, PubMed and The Cochrane Library before 1 April 2020. Reviewers included parallelRCTs that compared the effects of LLLT with placebo or different energy density LLLT for TMD patients’ pain reduction. Reviewers did network meta-analysis and evaluated the quality of evidence using the GRADE process. Results From 352 studies, reviewers included 16 RCTs. Immediately after treatment, the d1 laser therapy (energy density ranging from 0 to 10 J/cm2) ranked first. The d1 laser therapy showed more pain reduction than placebo ( MD = 2.49, 95% CI ranging from 1.28 to 3.71). The quality of “d1 vs p” comparison was assessed as “moderate” quality. A month after treatment, the d1 laser therapy also performed better than placebo (MD = 1.69, 95%CI = [-0.78, 4.16]). The quality of secondary outcome was assessed as “low” quality. Conclusions For clinical application, d1 laser therapy (energy density ranging from 0 to 10 J/cm2) is recommended for short-term pain management of TMD patients (moderate quality evidence). A month after treatment, the d1 laser therapy also performed better than placebo and other laser groups but the result didn’t reach the point of statistical significance (low quality evidence). Trial registration: PROSPERO-CRD42018118313. Keywords Temporomandibular joint disorders . Pain . Low-level light therapy . Meta-analysis . Systematic review . GRADE approach
* Guangjie Bao [email protected]
Yang Liu [email protected]
* Hong Kang [email protected]
Caiyun Yu [email protected]
Guoyi Jing [email protected] Yatao Zhao [email protected]
Jingjing Hu [email protected] 1
Department of Temporomandibular Joint and Occlusion, School/ Hospital of Stomatology, Lanzhou University, Dong Gang Xi Road 199#, Lanzhou 730000, People’s Republic of China
2
Department of Orthodontics, Xiangya Hospital and School of Stomatology, Central South University, Changsha 410078, People’s Republic of China
3
Key Laboratory of Stomatology of State Ethnic Affairs Commission, Northwest Minzu University, Lanzhou 730000, People’s Republic of China
Fangrui Dong [email protected] Pengfei Zhang [email protected] Hui Ren [email protected] Jingying Liu [email protected]
Lasers Med Sci
Background Temporomandibular joint disorders (TMD), a common musculoskeletal disorders involving temporomandibular joint and masticatory muscles, usually shows pain and other symptoms. According to report, TMD h
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