Effects of Saireito on the ovarian function of patients with polycystic ovary syndrome
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ORIGINAL ARTICLE
Effects of Saireito on the ovarian function of patients with polycystic ovary syndrome Machi Okamoto • Hideya Sakakibara • Hiroshi Yoshida • Yuka Fukazawa • Kunitomo Takashima • Yoshihito Kondo Mario Ikeda • Masahiko Ishikawa • Fumiki Hirahara
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Received: 28 December 2009 / Accepted: 28 May 2010 / Published online: 22 June 2010 Ó Japan Society for Reproductive Medicine 2010
Abstract Purposes It is sometimes difficult to restore a regular ovulatory cycle in women with polycystic ovary syndrome (PCOS) using classic agents such as clomiphene citrate or gonadotropins. Saireito, a herbal medicine, is believed to have an effect similar to corticosteroids. We examined the effect of Saireito on ovulatory induction and endocrine status in women with PCOS. Methods Twenty-four women with PCOS were treated with Saireito for 3 months. Serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), testosterone (T), estradiol (E2), adrenocorticotropic hormone (ACTH), and cortisol were measured before and after treatment, and ovulation was assessed. We compared serum LH levels between ovulation (n = 21) and anovulation (n = 3) groups, and compared ovulation rate and serum LH levels between obese (n = 6) and nonobese (n = 18) groups. Results Ovulation was restored in 21 (87.5%) of the 24 PCOS patients following administration of Saireito for 3 months. LH levels were significantly decreased 1 month
M. Okamoto (&) H. Yoshida K. Takashima M. Ishikawa Department of Gynecology, Yokohama City University, Medical Center, 4-57 Urafune-cho, Minami, Yokohama, Kanagawa 232-0024, Japan e-mail: [email protected] H. Sakakibara Y. Fukazawa F. Hirahara Department of Obstetrics and Gynecology, Yokohama City University, School of Medicine, 3-9 Fukuura, Kanazawa, Yokohama, Kanagawa 236-0004, Japan Y. Kondo M. Ikeda Ebina Ladies Clinic, 3-3-1 Chuo, Ebina, Kanagawa 243-0432, Japan
after medication in ovulatory group (P \ 0.001), but only slightly decreased in anovulatory group. Ovulation rate in the nonobese group (94.4%) was higher than in the obese group (66.7%). Serum LH levels were significantly reduced in the nonobese group, but only slightly reduced in the obese group. Conclusions Saireito reduced serum LH levels and increased ovulatory rate, particularly in nonobese women. Keywords Herbal medicine Luteinizing hormone Ovulatory induction Polycystic ovary syndrome Saireito
Introduction Polycystic ovary syndrome (PCOS) is one of the most frequent endocrinopathies, affecting 5–10% of women of reproductive age, and causing female infertility and menstrual disorder. This syndrome encompasses a broad spectrum of signs and symptoms of ovarian dysfunction. Consequently, PCOS has been associated with wide controversy in terms of both diagnosis and treatment. A major meeting in Rotterdam successfully reached a consensus of opinion regarding diagnosis of PCOS in 2003 [1]. In 2007, new diagnostic criteria for PCOS were adopted for use in Japanese clinics by the Japan Society of Obstetrics
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