Endocrine Mechanisms Connecting Exercise to Brown Adipose Tissue Metabolism: a Human Perspective
- PDF / 904,534 Bytes
- 16 Pages / 595.276 x 790.866 pts Page_size
- 84 Downloads / 120 Views
OBESITY (KM GADDE AND P SINGH, SECTION EDITORS)
Endocrine Mechanisms Connecting Exercise to Brown Adipose Tissue Metabolism: a Human Perspective Andrea Mendez-Gutierrez 1,2,3 & Francisco J. Osuna-Prieto 4,5 Guillermo Sanchez-Delgado 5,6,7
& Concepcion M Aguilera
1,2,3
& Jonatan R Ruiz
5,6
&
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose of Review To summarize the state-of-the-art regarding the exercise-regulated endocrine signals that might modulate brown adipose tissue (BAT) activity and/or white adipose tissue (WAT) browning, or through which BAT communicates with other tissues, in humans. Recent Findings Exercise induces WAT browning in rodents by means of a variety of physiological mechanism. However, whether exercise induces WAT browning in humans is still unknown. Nonetheless, a number of protein hormones and metabolites, whose signaling can influence thermogenic adipocyte’s metabolism, are secreted during and/or after exercise in humans from a variety of tissues and organs, such as the skeletal muscle, the adipose tissue, the liver, the adrenal glands, or the cardiac muscle. Summary Overall, it seems plausible to hypothesize that, in humans, exercise secretes an endocrine cocktail that is likely to induce WAT browning, as it does in rodents. However, even if exercise elicits a pro-browning endocrine response, this might result in a negligible effect if blood flow is restricted in thermogenic adipocyte–rich areas during exercise, which is still to be determined. Future studies are needed to fully characterize the exercise-induced secretion (i.e., to determine the effect of the different exercise frequency, intensity, type, time, and volume) of endocrine signaling molecules that might modulate BAT activity and/or WAT browning or through which BAT communicates with other tissues, during exercise. The exercise effect on BAT metabolism and/or WAT browning could be one of the still unknown mechanisms by which exercise exerts beneficial health effects, and it might be pharmacologically mimicked. Keywords Brown fat . Physical activity . Thermogenesis . Exercise physiology
Jonatan R Ruiz and Guillermo Sanchez-Delgado share seniorship. This article is part of the Topical Collection on Obesity * Jonatan R Ruiz [email protected]
4
Department of Analytical Chemistry, Technology Centre for Functional Food Research and Development (CIDAF), University of Granada, Granada, Spain
5
PROFITH “PROmoting FITness and Health through Physical Activity” Research Group, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain
6
Department of Physical Education and Sports, University of Granada, Granada, Spain
7
Pennington Biomedical Research Center, Baton Rouge, LA, USA
* Guillermo Sanchez-Delgado [email protected] 1
Department of Biochemistry and Molecular Biology II, “José Mataix Verdú” Institute of Nutrition and Food Technology (INYTA), Biomedical Research Centre (CIBM), University of Granada, Granada, Spain
2
Data Loading...
