Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer
Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer provides a current perspective on the epidemiology of head and neck cancer. Cancers of the oral cavity, pharynx, and larynx comprise an important group of tumors with diverse international
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Andrew F. Olshan Editor
Epidemiology, Pathogenesis, and Prevention of Head and Neck Cancer
Editor Andrew F. Olshan, Ph.D. Professor and Chair Department of Epidemiology 2101B McGavran-Greenberg Hall Gillings School of Global Public Health CB#7435 University of North Carolina Chapel Hill, NC 27599 [email protected]
ISBN 978-1-4419-1471-2 ISBN 978-1-4419-1472-9 (eBook) DOI 10.1007/978-1-4419-1472-9 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010921593 © Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Head and neck cancer – defined here as cancers of the oral cavity, pharynx, and larynx – comprises a fascinating tumor model. With two well established risk factors – tobacco and alcohol – and the potential for screening, these tumors provide unique opportunities for prevention and control. Further, the known etiological factors also help frame studies of mechanisms and susceptibility. Finally, the role of the human papillomavirus (HPV) offers another cancer model to investigate the viral etiology of cancer. This context has led to wonderful interdisciplinary research opportunities among clinicians, epidemiologists, and molecular biologists and geneticists. In that spirit, we have brought together the world’s experts on the epidemiology, clinical aspects, and molecular biology of head and neck cancer. The book includes a spectrum of research foci from descriptive epidemiology to molecular biology. I hope that active researchers in the field of head and neck cancer will find these current summaries useful to guide their research as well as drawing in those not working on this cancer. The book illustrates much of what is known and also highlights the many unanswered questions. I wish to thank the authors who worked so hard to develop their chapters. I also thank Rachel Warren of Springer Press for her editorial guidance. Chapel Hill, NC
Andrew Olshan, Ph.D.
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Contents
Classification, Clinical Features, and Molecular Genetic Models .............. Wayne M. Koch and Melonie Nance
1
Descriptive Epidemiology: U.S. Patterns ...................................................... Linda Morris Brown, Gloria Gridley, and Susan S. Devesa
23
Descriptive Epidemiology
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