Evaluation of the anti-inflammatory and antioxidant effects of the microalgae Nannochloropsis gaditana in streptozotocin
- PDF / 445,471 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 78 Downloads / 175 Views
RESEARCH ARTICLE
Evaluation of the anti-inflammatory and antioxidant effects of the microalgae Nannochloropsis gaditana in streptozotocin-induced diabetic rats Wassila Nacer 1 & Fatima Zohra Baba Ahmed 1
&
Hafida Merzouk 1 & Ouahiba Benyagoub 1 & Samira Bouanane 1
Received: 2 April 2020 / Accepted: 28 October 2020 # Springer Nature Switzerland AG 2020
Abstract Purpose This study aims to evaluate the anti-inflammatory and antioxidant effects of N. gaditana on streptozotocin (STZ)induced diabetes mellitus in Wistar rats. Methods Diabetes was induced in male Wistar rats by single intraperitoneal injection of STZ (45 mg/kg). Male rats were fed on control diet supplemented or not with N. gaditana (10%) for a period of 2 months. At the end of the experiment, biochemical parameters and oxidant/antioxidant markers in liver and pancreas tissues, as well as mitochondria isolated from liver of rats, were determined. Results It was notice that levels of glucose, glycated hemoglobin (HbA1c), lipid profile, kidney functions and liver enzymes in addition to markers of the inflammatory reactions interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) increased significantly (P < 0.05) in diabetic rats. Moreover, undesirable alterations of oxidative stress markers of tissue and mitochondria isolated from the liver were noted in these rats. N. gaditana supplementation was shown effective in lowering the levels of glucose, HbA1c and improving the renal and hepatic function and also in attenuating the oxidative stress and inflammation in diabetic rats. Conclusion N. gaditana possesses antioxidant properties that might have beneficial effect in treatment of diabetes. Keywords Nannochloropsis gaditana . Diabetes . Mitochondria . Oxidative stress . Inflammation
Introduction Diabetes mellitus is a group of metabolic disorders which are caused par absolute or relative deficiencies of insulin secretion that is associated with elevated levels of blood glucose and also with disturbances in the metabolism of carbohydrates, lipids, and proteins [1]. Diabetes affects individuals’ functional capacities and quality of life, leading to significant morbidity and premature mortality [2]. Streptozotocin (STZ) is a natural diabetic agent that is used to generate diabetic animal models by damaging or destroying the pancreatic β cells; this leads to the cessation of insulin * Fatima Zohra Baba Ahmed [email protected] 1
Laboratory of Physiology, Physiopathology and Biochemistry of Nutrition, Department of Biology, Faculty of Natural and Life Sciences, Earth and Universe, University Abou-Bekr Belkaïd, 13000 Tlemcen, Algeria
production [3]. On the other hand, STZ has drawn much attention as a potential source of oxidative stress that plays a pivotal role in the development of diabetes and its complications [4, 5]. During diabetes, inflammation can be triggered by increased ROS (reactive oxygen species), which activates several inflammatory signaling cascades. In addition, the condition of diabetes can increase the availability of free fatt
Data Loading...
