Exercise-induced GH secretion is related to puberty
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ORIGINAL ARTICLE
Exercise‑induced GH secretion is related to puberty C. Bizzarri1 · D. Colabianchi1 · G. A. Giannone2 · L. Di Luigi3 · M. Cappa1 Received: 2 June 2020 / Accepted: 14 September 2020 © Italian Society of Endocrinology (SIE) 2020
Abstract Purpose Exercise represents a physiological stimulus that initiates the coordinated responses of hypothalamic–pituitary axis and sympathetic nervous system. Aims of the study were: 1) to analyze the response of GH, cortisol and prolactin to acute exercise in healthy children with normal GH response to stimulation tests 2) to evaluate the reliability of physical exercise as a screening test for GH secretion. Methods Forty-four children (mean age 9.35 ± 2.69 years, range 4–13.7) underwent standardized Bruce’s test on treadmill. Twenty-nine children were pre-pubertal (nine females and 20 males) and 15 children were pubertal (ten females and five males). Results Exercise elicited a peak secretion of all the analyzed hormones. GH showed the highest mean percentage increase (558%), followed by prolactin (178%) and cortisol (23%). In 19/44 children (43.2%), GH peak did not reach the cut-off level of 8 ng/ml, considered as the normal GH response to stimulation tests. Despite a wide inter-individual variability, both GH peak and GH increase from baseline were higher in pubertal children than in pre-pubertal ones (GH peak: 13.49 ± 10.28 ng/ ml versus 6.6 ± 4.09 ng/ml—p
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