Experimental autoimmune prostatitis: different antigens induction and antigen-specific therapy

  • PDF / 1,872,528 Bytes
  • 12 Pages / 595.276 x 790.866 pts Page_size
  • 18 Downloads / 212 Views

DOWNLOAD

REPORT


UROLOGY - REVIEW

Experimental autoimmune prostatitis: different antigens induction and antigen‑specific therapy Yuqian Liu1 · Junaid Wazir1   · Meng Tang1 · Rahat Ullah1 · Yueting Chen1 · Tingting Chen1 · Xiaohui Zhou1,2  Received: 19 August 2020 / Accepted: 29 October 2020 © Springer Nature B.V. 2020

Abstract Purpose  Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) has uncertain etiology and lacks effective treatment. Autoimmunity is an important pathogeny, and experimental autoimmune prostatitis (EAP) models have long been used for studying CP/CPPS. This review presents the detailed current knowledge of EAP models based on evaluation criteria aspects to provide a tool for model selection in pathogenesis studies and therapeutic drug screening. Methods  We extensively searched the published literature on CP/CPPS and different antigen-induced EAP models focusing on the histopathology, clinical-related phenotypes, and biochemical indicators. We also cover the changes in the prostate function and other organs in EAP. Finally, we try to get some insights about antigen-based therapeutic approaches for CP/CPPS. Results  Several inciting autoantigens were reported in EAP, including male accessory gland extracts, prostate extracts (PE), prostatic steroid-binding protein, prostatic spermine-binding protein (p25), prostatic acid phosphatase, seminal vesicle secretory protein 2, and T2 peptide. All of these models mimicked histological prostatitis, however only p25- and T2-induced models developed both pelvic pain and voiding behaviors. PE immunization is the most widely used method. Diminished fertility and mental health disorders can be found in PE model. Oral and intravenous T2 peptide have been studied for antigenspecific therapy and achieved preliminary progress in EAP models. Conclusions  PE-induced model is the most commonly used, while T2- or p25-model could serve as a promising CP/CPPS model. Antigen-specific therapy in CP/CPPS deserves further study. Keywords  Chronic prostatitis/chronic pelvic pain syndrome · Experimental autoimmune prostatitis · Autoantigens · Histopathology · Animal model

Introduction Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) (category III) is one of the common diseases in urology and has a prevalence rate ranged from 5 to 14.2% in the general population [1, 2]. The long-term and repeated pelvic pain seriously affects the patient’s quality of life. Aside from the local damage and inflammation of the prostate, CP/CPPS patients may also have painful bladder filling and/or painful urinary urgency [3], irritable bowel syndrome [4], structural * Xiaohui Zhou [email protected] 1



Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, Jiangsu, People’s Republic of China



Department of Surgery, Nanjing Shuiximen Hospital, Nanjing 210017, Jiangsu, People’s Republic of China

2

and functional brain changes [5], greater endothelial dysfunction and arterial stiffness [6], depression and panic disord